Protein Info for Echvi_4117 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1481 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 344 to 361 (18 residues), see Phobius details amino acids 367 to 387 (21 residues), see Phobius details amino acids 393 to 417 (25 residues), see Phobius details amino acids 449 to 468 (20 residues), see Phobius details amino acids 480 to 504 (25 residues), see Phobius details amino acids 547 to 567 (21 residues), see Phobius details amino acids 888 to 907 (20 residues), see Phobius details amino acids 914 to 933 (20 residues), see Phobius details amino acids 939 to 961 (23 residues), see Phobius details amino acids 989 to 1010 (22 residues), see Phobius details amino acids 1018 to 1041 (24 residues), see Phobius details amino acids 1061 to 1078 (18 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1054 (1054 residues), 1153.8 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1044 (1040 residues), 900.5 bits, see alignment E=1.4e-274 PF02321: OEP" amino acids 1307 to 1456 (150 residues), 35.9 bits, see alignment E=6.5e-13

Best Hits

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G265 at UniProt or InterPro

Protein Sequence (1481 amino acids)

>Echvi_4117 heavy metal efflux pump (cobalt-zinc-cadmium) (Echinicola vietnamensis KMM 6221, DSM 17526)
MINKIISFSIKNKFIVGLLTLALIGVGIYSMSTVNLGSVPDITNNQVQVITVSPNLATED
IEQFVTYPVELAMGNLPGVDEIRSISRFGLSVVTIVFEDDMGTYLPRQLVQEKLNELQET
IPQKFGSPTMGPISTGLGQIYEYTIQPQEGYESQYSPMELRTIQEWIVKRQLTLLDGVVE
VNSFGGYIKQYEVAINPEKLNAMNVSISEVYEALARNNVNTGGAYIEKNRMSNFIRGEGL
VRSLDDIRKIVITTENGLPITIGDVAEKVHFGNQVRYGAFTQDGKEAVGGIIMMLKGSNP
NAVIQNVKERMEEVEKSLPEGLAINSIIDRSDLISRTTDTVKQNLIEGALIVIFALVILL
GSLRGGIITATTIPLSLLFAFILMKQFNVWANLMSLGAIDFGIIIDGAVIIIEGTVYEIQ
KRIRSGKIKFNQVVMDEVAYDAGSTMMSSAFFGQIIILIVFAPILFLTGVEGKMFQPMAY
TFGFAMIGAIILCLTYVPMMSALFMKPIQNKKNWFGRFERWLEKVSDKIIGGIQYAYLPL
LKSALRFKAVVIIVAIVLLGLAGFIFSRMGGEFVPQLDEGDIAMQALIRPGSSLSESKDV
SIKIEELLLKSFPEIKTVTARIGVADIPTDPMPMDIADMYLILEKDKDQWVSAETKDELI
EQIKDKLETNMTGVNLVFTQPVELRFNELLEGVREDIAVKLYGEDLEMLSAKVQEMADII
STVPGAGDVNPERTSGLPQMTVRYNRDKVAQYGLDIQKLNEYVSTAFAGGVAGVIFEGEK
RFDLVIRFDEAHRKSIDDLRTLYIDLPDGTQVPIKEVADISYVPGPMQISRDNTYRRTYV
GVNVRGRDVESVVNDIQEKLDSELDLPAGYYISYGGEFENLQRAKQRLQIVVPIALFLIF
VLLYFALKSFSQSIMIYIAIPLAAIGGVFALWLRDMPFSISAGVGFIVLFGVAVLNGLVL
INRFNSLKEEGVTSIRDRILTGTKERIRPIMLTATTDIFGFLPMAFSASAGAEVQRPLAT
VVIGGMLTATLLTLVVLPVLYTFVEGRSDKRKGLQTPNTNLILVLFMVSGLVGLPSLANA
QRSQENLTERQSDYDSLPTITLEQAKKKAIESYPKIQLARLEIENQEVLKKTAWDFGNTQ
VFTGREEVGSGSEVSSGGVYTQIGIQQQQIDVFGIAPRLRLQKERVALAEDALNLSVIEL
EREVSRAWAQVYTTKSQYLVYEQLDSLFIDIERAARIRLETEATSKLEYLATSNQANQVQ
IQKEQAYRDYLSALQRLNLWFANDTLFNVPDIATNQLDQPLNYMADSLMNHPMLNVSRQQ
VDVANAMIKERRAQFLPQLQGQYGKQQVDGQSGFYTYQIGIRIPLLFGPELGRTQSAKIQ
RDIAGQNLRQTQMELNTAYQNMRERYLKWRNSWVYYREEALPLAREQQAGAVTAYREGAI
DYVTFLQNIRDAIRIEVDSWDAFGNYLDSRYQLEYYLKTSN