Protein Info for Echvi_4110 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 831 transmembrane" amino acids 195 to 214 (20 residues), see Phobius details amino acids 220 to 238 (19 residues), see Phobius details amino acids 250 to 266 (17 residues), see Phobius details amino acids 272 to 290 (19 residues), see Phobius details amino acids 438 to 457 (20 residues), see Phobius details amino acids 469 to 493 (25 residues), see Phobius details amino acids 783 to 802 (20 residues), see Phobius details amino acids 808 to 827 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 252 to 825 (574 residues), 603.1 bits, see alignment E=9.4e-185 PF00122: E1-E2_ATPase" amino acids 302 to 497 (196 residues), 185.4 bits, see alignment E=7.6e-59 TIGR01494: HAD ATPase, P-type, family IC" amino acids 384 to 802 (419 residues), 207.4 bits, see alignment E=4.6e-65 PF00702: Hydrolase" amino acids 516 to 734 (219 residues), 123.8 bits, see alignment E=1.2e-39

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 70% identity to shg:Sph21_0227)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G4R1 at UniProt or InterPro

Protein Sequence (831 amino acids)

>Echvi_4110 heavy metal translocating P-type ATPase (Echinicola vietnamensis KMM 6221, DSM 17526)
MKKLQIQISVMLPEVPDEKDQCVDKLISRLQDTQGLEKVHVADETDNGVPQLCFHYDPEV
ISIDRIQKLAGQTGAEITEKFGHKLIEVEGIRHTRHARNVERNLRNKGGVLEASVSGSGM
VRLEFDTSKIDEAEILKVLRKEGLDIPDTRVSAERFLQQSSKSESKETQEREHDHEKGED
HDHSHGGIFGKNTELIFSIICGSLLGIGFGLSYIEAVPSLVSLILYIAAYFFGGYFTAKE
AIQTVAKGGFEIDFLMLVAAIGAAILGEWAEGALLLFLFSMGHALEHYAMNKARKSIAAL
AELAPKTALLKRNGKTEEVGIEELSIGDIIVVKPNSKISADGVVVDGRSSVNQAPITGES
VPVDKEPVDDPDKDWSQESEIKDENRVFSGTINGNNTLEIKVIKEAKDSTLSRLVKLVNE
AQTQKSPTQRFTDKFEKYFVPSVLALVVLLNFAFLVIDETFSESFYRSMAVLVAASPCAL
AISTPSAVLSGVARAAKSGVLIKGGRPLEDLGVLTALAFDKTGTLTEGKPNLTEVIALGE
VGEEELLKTAIAVENLSDHPLAKAVVRDGKERLKGADIPEAKDLEAVLGKGIKATLGSDK
VYIGNLDLFESLDDKKPSKEIEEKVKSLESDGNTTMLIRQNDSYIGIIALMDTPREEAKN
TLAQLKKIGVKRMIMLTGDNQKVADAVAKEIGLTDAWGSLLPEEKVEAIKELRQKEDKVA
MVGDGVNDAPAMANSTVGIAMGAAGSDVALETADIALMADKLETLPFAIGLSRKAKGIIK
QNLWMSLGIVALLIPATIFGFANIGIAVLIHEGSTLIVVFNALRLLAYKNT