Protein Info for Echvi_4014 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Beta-lactamase class C and other penicillin binding proteins

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 493 PF00144: Beta-lactamase" amino acids 7 to 336 (330 residues), 205.8 bits, see alignment E=1e-64 PF11954: DUF3471" amino acids 392 to 491 (100 residues), 57.9 bits, see alignment E=1.1e-19

Best Hits

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 52% identity to fjo:Fjoh_0467)

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5C7 at UniProt or InterPro

Protein Sequence (493 amino acids)

>Echvi_4014 Beta-lactamase class C and other penicillin binding proteins (Echinicola vietnamensis KMM 6221, DSM 17526)
MTSDHIDHLVDDARTRLDFPGIAVGVVKDGEVVHVKGYGVSSLASGKRVDRHTQFTLASV
SKAFTTTALAILVDRGEISWKDRVIDYIPEFTMYNSYVLDNFIIEDLLTHRSGLGLGVGD
LMFKPDDNDFTIDDILASFQHFEPVSAFRTQYDYDNLLYIVAGELIKRVTGQSWKVFVRD
NILVPLEMDNSFSEISLITDKGNLASPHVEKDDAVLEPIENFKRTGNGAASGIFSNVDDF
CKWMLVHLNRGKYGNDLEKELFSEERQREMWKPYISFVSHPTEPYFVNFSGYGLGWVLTD
VQGHFVAYHSGGLPGISTQIMLVPDMDLGIVVLANRGWSVEPISFAILDSYLGVPDQHWV
AKMAEGMKGTQQKTDSVSQNVWKTVAISATDRPDPKNFLGIYEDPWFGKVAVFEKGELLW
IKSYRAPKLNGELQYYKGSTFAVKWEYQDMNADAFVHFILDEKGIGQKISMEGISPDIDF
SFDFQDLDFSRCE