Protein Info for Echvi_3954 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: exodeoxyribonuclease VII, large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 PF13742: tRNA_anti_2" amino acids 5 to 111 (107 residues), 67.4 bits, see alignment E=1.1e-22 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 6 to 430 (425 residues), 295.4 bits, see alignment E=3.8e-92 PF02601: Exonuc_VII_L" amino acids 135 to 428 (294 residues), 213.8 bits, see alignment E=4.4e-67

Best Hits

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G1T0 at UniProt or InterPro

Protein Sequence (437 amino acids)

>Echvi_3954 exodeoxyribonuclease VII, large subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MQHPLSLSELNQLIQQALDIQLHPSYWVIAEIGELRDSPRGHAYLELVEKTDQQILAKIR
GNIWSYTYRGISSRFSSITGQSLKPGMKVLAQVSVQFHEVYGLSLNIKDIDPNFTLGEKA
RKRQETIDRLTKEGLMELNRQFILPQVPQRVAIISSANAAGFEDFINQVDHNREGFQVHW
KLYQATLQGDQAAASMTLAIEQVEMANQAHPFDLLVIIRGGGAQLDLDCFDDYGLAKAIA
NTTLPVVTGIGHERDESIVDMVAHTKMKTPTAVAAFILEGFREFEDLLEKHLKILERNAA
YHLQKEERKISQHGHLLKSLFQNQKNRAQERTNLLQYRIRSLANQAIKLRSHQLETMEGI
FKKEVQGILQQQKDKMESLKTDLIRLDPATFFKKGYTRSEINGLPISKANPQEGDQLTTY
GAKTTIQSTIKSIENHE