Protein Info for Echvi_3770 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: 2-keto-3-deoxy-6-phosphogluconate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01081: Aldolase
  • amino acids 13 to 189 (177 residues), 124.7 bits, E=1.7e-40

Best Hits

Swiss-Prot: 31% identical to ALKH_HAEIN: Putative KHG/KDPG aldolase (eda) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 50% identity to fbc:FB2170_02040)

Predicted SEED Role

"4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• D-galacturonate degradation I (5/5 steps found)
• D-fructuronate degradation (4/4 steps found)
• superpathway of β-D-glucuronosides degradation (6/7 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (13/17 steps found)
• Entner-Doudoroff pathway I (7/9 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (4/5 steps found)
• trans-4-hydroxy-L-proline degradation I (4/5 steps found)
• Entner-Doudoroff shunt (1/2 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
• D-glucosaminate degradation (1/3 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (14/31 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glyoxylate and dicarboxylate metabolism
• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.14, 4.1.3.16

Use Curated BLAST to search for 4.1.2.14 or 4.1.3.16

Sequence Analysis Tools

See L0G383 at UniProt or InterPro

Protein Sequence (214 amino acids)

>Echvi_3770 2-keto-3-deoxy-6-phosphogluconate aldolase (Echinicola vietnamensis KMM 6221, DSM 17526)
MSMTRTEIGDFILQEKLIAILRVSDAGTLPVLIAGLVKGGVKVLEITTNSPDYAAQIKEN
RQLYPDILIGAGTVINEASAKEAIAAGAQFLVSPNTHVGVISLAHAHGIPVIMGALTPTE
IGLALENGADMIKLFPAGDVGPGYLKSIKAPFDNARIFAVGGIHLETIHSWMEAGADGIG
LGSVLTQLAGLKLTEEVVAHNVRKYTEKIKEYVQ