Protein Info for Echvi_3645 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Isocitrate dehydrogenase kinase/phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 575 PF20423: AceK_regulatory" amino acids 11 to 309 (299 residues), 382.7 bits, see alignment E=1.2e-118 PF06315: AceK_kinase" amino acids 310 to 565 (256 residues), 389.8 bits, see alignment E=5.9e-121

Best Hits

Predicted SEED Role

"Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)" (EC 2.7.11.5, EC 3.1.3.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.-

Use Curated BLAST to search for 2.7.11.5 or 3.1.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G4V0 at UniProt or InterPro

Protein Sequence (575 amino acids)

>Echvi_3645 Isocitrate dehydrogenase kinase/phosphatase (Echinicola vietnamensis KMM 6221, DSM 17526)
MSTATQPLVVQKIIDAYHKYITSFHEHTKRAPIYFRERDWDGVQLNHRQRLRLYKDCVNE
VVASCKESYGEYLKDRQFWIDVKTAFSKAINTRKDKELAESFYNSVIRKAVSDLSIDEEL
MYVLEGYDSCEIHSQEPLFHNYPSHWGVQKIIRKILEDFDFQAPYYQREKDVQYLVRSIR
EVILTRYKVDENTTTQVLKQVFYRNKAAYLIGRTFLGGKWMPFIIPFLNGPKGIYVDTLI
FDPNLMSAIFSYTRSYFMVETEIPSQIVAFLNSVIRHKKVYELYNAIGFNKHGKTEFYRD
FLNHLNTSNDQFTVAPGIKGMVMTVFTLPSYNIVFKVIKDHFDPPKNMTRQEVKDKYRLV
SLHDRVGRMADTHEFEYFQIPMDRVHPDLLKELKNTVNSLIKIDGDTLFIKHLYTERRLT
PLNMYLEDCTLEDAKIAVEEYGNAILQLAKANIFPGDMMTKNFGVTRQKRVIFYDYDEIE
FLTKMNFRIKPKPVTFDQIYASRPWYEIAKNDVFPEDFKRFMIGRSDIKPHFFEFHKLLF
DPEHWQKIQGRIEHGELIHAFPYPEYMRFRPEEEV