Protein Info for Echvi_3630 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Entner-Doudoroff aldolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 44% identity to fbc:FB2170_15053)Predicted SEED Role
"4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-galacturonate degradation I (5/5 steps found)
- D-fructuronate degradation (4/4 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (13/17 steps found)
- Entner-Doudoroff pathway I (7/9 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (7/9 steps found)
- 4-deoxy-L-threo-hex-4-enopyranuronate degradation (4/5 steps found)
- trans-4-hydroxy-L-proline degradation I (4/5 steps found)
- Entner-Doudoroff shunt (1/2 steps found)
- 3,6-anhydro-α-L-galactopyranose degradation (4/7 steps found)
- D-glucosaminate degradation (1/3 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (14/31 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Glyoxylate and dicarboxylate metabolism
- Pentose and glucuronate interconversions
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 4.1.2.14, 4.1.3.16
Use Curated BLAST to search for 4.1.2.14 or 4.1.3.16
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0G4T4 at UniProt or InterPro
Protein Sequence (222 amino acids)
>Echvi_3630 Entner-Doudoroff aldolase (Echinicola vietnamensis KMM 6221, DSM 17526) MKFSNSEIIEAMEKTGMIPVFNHSDLEVAKNVMDASYNGGVRVFEFTNRGENALEVFREL KAYSSRHKGLMLGIGTIFTPKEVEDFIEAGADFIVSPALIPNVAVTATRNDTLWIPGCGT VTEIFNAREMGAQVIKAFPGNVLGPSFISAVKAVLPSLKIMPTGGVEPTEENLGQWFKAG VTCVGMGSQLFKKDWIKQKKFDALEKQISEALDTIQRIRNSQ