Protein Info for Echvi_3496 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: DNA repair exonuclease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 616 PF00149: Metallophos" amino acids 20 to 205 (186 residues), 35.9 bits, see alignment E=5.7e-13

Best Hits

Predicted SEED Role

"Calcineurin-like phosphoesterase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G2F1 at UniProt or InterPro

Protein Sequence (616 amino acids)

>Echvi_3496 DNA repair exonuclease (Echinicola vietnamensis KMM 6221, DSM 17526)
MFAPLWTNQAFGQKADRHQVAFLADVHLQVVYADLHDSDFKGIWNPKTSQYATIRTMKAQ
INSTRLFNENYFAFHEALQKVVDQGIKVVVLPGDFTDDGQPMNLEALQRILAQFAAAYDL
RFYLTTGNHDPVTVTRSPGGKFDFMGPEGRPQALVSDSSFLKADLPADLPIAISEQIAYG
GYEDILEQLGDFGFYPSEKDLFWTHPFEPLDYEGYRFQKAHENAALAKRYFKSSSTDSLP
DLSYLVEPVEGIWLLGIDANVYFPVSGTKTFKGSSVGFNLAKDYKSHQLEWIKKIAEEAE
RRGKTLVSFSHYPLVEFNAGSDELLKRTFGPSKFQLARSPRPEIAAAYANAGIKVHVAGH
MHLNDTGIFTTESGNTLVNIQVPSLAAYPPAFKVLTFGQDKAIEVETQRLREVEQMGEFF
PLYLQEHEYLEGQQAQNIWKKGILDASNYLEYTSHHLSELVRLRFIPSDWPEDHAKQLLS
LNGLELAYWASLENSNVRQEFLVHKAIPVPFLKQFKRQLKGKSITPATLANMDGLDLITT
FYFVKNGDQLAQKDIEKAQWEAMYFLMESVAKLTPDQQEDFGHFMVNFSGIFMAMTNDIP
SDHFRIDLKQGTVEAL