Protein Info for Echvi_3352 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: drug resistance transporter, Bcr/CflA subfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 45 to 64 (20 residues), see Phobius details amino acids 76 to 94 (19 residues), see Phobius details amino acids 100 to 121 (22 residues), see Phobius details amino acids 133 to 155 (23 residues), see Phobius details amino acids 162 to 183 (22 residues), see Phobius details amino acids 213 to 231 (19 residues), see Phobius details amino acids 251 to 271 (21 residues), see Phobius details amino acids 282 to 300 (19 residues), see Phobius details amino acids 307 to 331 (25 residues), see Phobius details amino acids 342 to 363 (22 residues), see Phobius details amino acids 370 to 389 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 6 to 385 (380 residues), 342.6 bits, see alignment E=1.9e-106 PF07690: MFS_1" amino acids 16 to 355 (340 residues), 175.7 bits, see alignment E=2e-55 PF00083: Sugar_tr" amino acids 44 to 185 (142 residues), 50.2 bits, see alignment E=3e-17

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 64% identity to dfe:Dfer_1982)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G429 at UniProt or InterPro

Protein Sequence (412 amino acids)

>Echvi_3352 drug resistance transporter, Bcr/CflA subfamily (Echinicola vietnamensis KMM 6221, DSM 17526)
MSKKQYFVVILILGALSTISPFSIDMYLPGFPSIAKNLGTSIANVQLSLTSYLVGIAIGQ
LFYGPLLDRFGRKKPLYIGLLIYVLASMACAWSNSVENLILMRFVQAIGGCAGMVAAQAM
VRDIFPVNKTAQAMALLMLVIAVSPMIAPTVGGFVTAHYDWHTVFMILAGITLVILMASY
FFLPDGAKPDHEVSLKPKQVVKKYVEVTKNRQFLVYMLIGGVAGAAPFAYISGSADVFMN
IYGVTEQQYGWIFALLAFSMIGSTQLNHILLKKFTSEQIIKVALTYQTIIGFAMILGVWN
GWLNVYTLIGMMFIFLTGHGLCNPNAAALTLAPFSRNAGSAAAMMGSMRMAMGGVVSGAV
SIFHNGTASPMVIMMTFCAVGGLLTLVIDTNQKKVEKKRKALEDEKHHSMAV