Protein Info for Echvi_3337 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Predicted hydrolase of the alpha/beta-hydrolase fold

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 325 PF12146: Hydrolase_4" amino acids 60 to 270 (211 residues), 42.4 bits, see alignment E=7.8e-15 PF00561: Abhydrolase_1" amino acids 62 to 300 (239 residues), 33.9 bits, see alignment E=4e-12 PF12697: Abhydrolase_6" amino acids 67 to 297 (231 residues), 28.3 bits, see alignment E=4.2e-10

Best Hits

KEGG orthology group: K07019, (no description) (inferred from 50% identity to mtt:Ftrac_0680)

Predicted SEED Role

"Hydrolase, alpha/beta fold family functionally coupled to Phosphoribulokinase" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G418 at UniProt or InterPro

Protein Sequence (325 amino acids)

>Echvi_3337 Predicted hydrolase of the alpha/beta-hydrolase fold (Echinicola vietnamensis KMM 6221, DSM 17526)
MPLIKNSTYLGPPRLYFNGHFETILPSVFRKIQGVTYQRERIDTVDGDFLDLDWSEVGSK
KLLIVSHGLEGNSGRHYVTGLVKLFNQHQIDVLAWNNRSCSGEMNLRPVLYHHGASDDLK
AVVDHVVSNREYEGIYLAGISMGGAQTLKYLGEEGAMLSSSIKGAAVYSTPCNLPDSAAT
LRLPRNVFYKNKFLAKLKVKMAEKAKQFPGIIDEELLQKVKDFDVFDDHFTAKLHGFKDG
QDFYHSVSPDNWMQQITIPTLIVNALNDPLLMDRCYPVQLASQHDQVYLEMPKRGGHTGF
AVSGQEFSWVERRLLQFLTVQDPDS