Protein Info for Echvi_3315 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 876 PF00521: DNA_topoisoIV" amino acids 41 to 452 (412 residues), 352.6 bits, see alignment E=1.6e-109

Best Hits

KEGG orthology group: K02621, topoisomerase IV subunit A [EC: 5.99.1.-] (inferred from 74% identity to mtt:Ftrac_0640)

Predicted SEED Role

"Topoisomerase IV subunit A (EC 5.99.1.-)" in subsystem DNA topoisomerases, Type II, ATP-dependent or Resistance to fluoroquinolones (EC 5.99.1.-)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.-

Use Curated BLAST to search for 5.99.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G2M1 at UniProt or InterPro

Protein Sequence (876 amino acids)

>Echvi_3315 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MSDIENNGQGENGDALHDSVPVTGMYQEWFLDYASYVILERAVPAIEDGFKPVQRRILHA
MKEMDDGRFNKVANIIGQTMQYHPHGDASISDAIVNLGQKDLLIETQGNWGDIRTGDGAA
AARYIEARLSKFALEVVFNPQTTDWQVSYDGRKREPVTLPVKFPLLLAQGVEGIAVGLST
KILPHNFCELINASVDVLKGKKANIVPDFPTGGLADFSEYNEGLRGGKIKVRARIEEGDG
KSLLIKDIPFGTTTTSLIDSIIKANDKGKIKIKKVVDNTAKDVEIQVFLAPGQSPDMTID
ALYAFTDCEQSISPNACVIIDDKPVFMGVNDILAYNTTQTKALLKRELEIRKGELMEKLL
FSSLEKIFIENRIYRDIEECETWEDVIDTIDKGLDPHKPDFYREITKDDIIRLTEIKIKR
ISRFDSFKADELMRKLEDELKEVEYNLEHLTEFAIDYYKNLLKKYGKGRERKTEIRNFET
IQATVVAANNAKLYVNRKDGFIGLGLKKDEFVCDCSDLDDIIAFKKDGTCVVTKIQDKVF
VGKDIIHVGVFRKGDERMVYNMIYLDGASGRTMVKRFQILSVTRDREYVLTKGTKGSKVL
YFTANPNGEAEIVTVYLTQGSKARVKVFDFDFKELDIKGRGAGGNILTKYPVRKIQLKME
GGSTLGGLDVFYDEAVGRLNTDERGRLIGNFLGDDKVIAFYKDGSYELTSYELTNRYDPN
TLMLIEKFDPQAVISCVYYDGASKNHYVKRFNIETSTMGKKFTFISDHRRSTLEIVSTDK
QPQVAVTLKKGQETEKVEYDLDMLIDVKGWKSVGNKLSAHTVKSIKLLEPVKKETGTKEE
NGNKDDLEVGSTIDLNVKKDDDDDDKDQLGLFKNGK