Protein Info for Echvi_3166 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: putative thymidine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 TIGR02645: putative thymidine phosphorylase" amino acids 8 to 496 (489 residues), 600.1 bits, see alignment E=1.3e-184 PF02885: Glycos_trans_3N" amino acids 102 to 160 (59 residues), 39.9 bits, see alignment 4.4e-14 PF00591: Glycos_transf_3" amino acids 169 to 398 (230 residues), 54.5 bits, see alignment E=2.1e-18 PF07831: PYNP_C" amino acids 431 to 488 (58 residues), 27.2 bits, see alignment 3.6e-10

Best Hits

Swiss-Prot: 56% identical to TYPH_LEGPC: Putative thymidine phosphorylase (LPC_2257) from Legionella pneumophila (strain Corby)

KEGG orthology group: K00758, thymidine phosphorylase [EC: 2.4.2.4] (inferred from 96% identity to zpr:ZPR_3410)

Predicted SEED Role

"Thymidine phosphorylase (EC 2.4.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 2.4.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G253 at UniProt or InterPro

Protein Sequence (500 amino acids)

>Echvi_3166 putative thymidine phosphorylase (Echinicola vietnamensis KMM 6221, DSM 17526)
MDTHSNILKYKHLGIYTQNENVVYMREDCHVCISEGFEALTRIRISNANTSIVASLNVLN
SDILLPNEIGLSDAAAKKLNVSQNDTLYVSHLEPIESLSHVRAKIYNKKLDYKAYNNIIT
DIVEGDYSNIHLSAFITACAGDRMDIDEISDLTKAMIASGKQLNWNKDIVVDKHCIGGLP
GNRTTPLVVAIVAAYGLTMPKTSSRAITSPAGTADTMEVLTNVTLSSEEIKTVVEKEGGC
FVWGGTAQLSPADDVLIKIEKALDIDSEGQLIASVLSKKAAAGSTHVVIDIPVGETAKVR
STEMAEKLKNHMETVGTAVGLNVKVVVTDGTQPVGRGIGPTLEAIDILKVLKNEEDAPKD
LTERALLLATELLELSGKVEKGKGLETAHKILKSGKAYEKFIAICKAQGQFSKPVLAPYK
IEIKAEKSGVLQRIDNRKIAKLAKLSGAPQSKSAGILLNVHLNEKIEIDQLLYTIYAESK
GELNYALEYKNNHNDIITII