Protein Info for Echvi_3165 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Predicted exonuclease of the beta-lactamase fold involved in RNA processing

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 PF00753: Lactamase_B" amino acids 21 to 199 (179 residues), 57.9 bits, see alignment E=3.5e-19 PF16661: Lactamase_B_6" amino acids 24 to 193 (170 residues), 33.3 bits, see alignment E=8e-12 PF12706: Lactamase_B_2" amino acids 29 to 213 (185 residues), 41.4 bits, see alignment E=3.1e-14 PF10996: Beta-Casp" amino acids 253 to 372 (120 residues), 111.4 bits, see alignment E=9.9e-36 PF07521: RMMBL" amino acids 386 to 449 (64 residues), 71.8 bits, see alignment E=9.8e-24

Best Hits

KEGG orthology group: K07576, metallo-beta-lactamase family protein (inferred from 92% identity to zpr:ZPR_3409)

Predicted SEED Role

"Metallo-beta-lactamase family protein, RNA-specific" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G1H7 at UniProt or InterPro

Protein Sequence (458 amino acids)

>Echvi_3165 Predicted exonuclease of the beta-lactamase fold involved in RNA processing (Echinicola vietnamensis KMM 6221, DSM 17526)
MTNNKINIHFLGAAGTVTGSKYLVDTGDRKILIDCGLFQGLKELRLKNWEYPPVNVADID
AVLLTHGHMDHTGYLPRLVKQGFKGPIYGTNPTLDIAKIILNDSAKIQEQEAERANKEGY
SKHSPAEPLYDLNDVEKTIPYFKGVPPSQWLPILKDVKARFQYNGHILGATYIELDIRGK
RFVFSGDIGRTNDLLLFPPLKPKEADVLFIESTYGGRFHPDEVEALPQIEKLVNDTINRG
GSLFVPSFSVERAQLMMLIFWRLLKENKIPKVQMIMDSPMGANVLELFHRTRDWHRLEDN
ECDEMCSYFTVISSYRETMELRTDNKPKIVIAGSGMLTGGRMLNYLETQAQNPNNTLLFV
GYQAEGTRGRKLLEGEKELKVYGKWVPFKMQVAEIEGLSAHADHAELMDWMDSIKNKPKR
IFIIHGEKESAEALQKGIKETYGWDAEIPQLYTIEEIE