Protein Info for Echvi_3072 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Glucuronate isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to UXAC_BACTN: Uronate isomerase (uxaC) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
KEGG orthology group: K01812, glucuronate isomerase [EC: 5.3.1.12] (inferred from 68% identity to fbc:FB2170_10646)MetaCyc: 54% identical to D-glucoronate/D-galacturonate isomerase (Escherichia coli K-12 substr. MG1655)
Glucuronate isomerase. [EC: 5.3.1.12]; 5.3.1.12 [EC: 5.3.1.12]
Predicted SEED Role
"Uronate isomerase (EC 5.3.1.12)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 5.3.1.12)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (9/10 steps found)
- D-galacturonate degradation I (5/5 steps found)
- superpathway of β-D-glucuronosides degradation (6/7 steps found)
- pectin degradation II (4/5 steps found)
- β-D-glucuronide and D-glucuronate degradation (2/3 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (14/31 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.12
Use Curated BLAST to search for 5.3.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0G389 at UniProt or InterPro
Protein Sequence (481 amino acids)
>Echvi_3072 Glucuronate isomerase (Echinicola vietnamensis KMM 6221, DSM 17526) MLDEVSNRLRKTKKTFLSEDFLLQSEFAQVLYHDYAKELPIIDYHCHLSPKDITENRTFK NLTEIWLAGDHYKWRAMRTLGIDEKYITGKGSTDQEKFQKWAETVPYTLRNPLYHWTHLE LKRYFGIEELLSPDTADDIYQKATDMLQQPSHHTRGLLSQMNVETVCSTDDPIDSLEYHI KAKKEGIQPNLFPAFRPDKAYAVENPADYMAYLEKLQEASGVTISKYGDLLAALENQIAF FHEHGGRLSDHGLEQLYFFKLGQYSAEDLFQKLSEQKALSNEEIQYFKFETLLHLSHMYH AKGWTQQYHLGALRNTNERMLRVLGPDTGFDSIGDYSQAEALAKFLNQLDSTDQLTKTIL YNLNPRDNEVLATMIGNFNDGSIRGKVQFGSGWWFLDQKDGMEKQLNALSNMGLLSCFVG MLTDSRSFLSFPRHEYFRRTLCNLIGRDVENGELPADEKWLGKIVSDICYYNAKNYFEFE Q