Protein Info for Echvi_2990 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Acyl-CoA dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 402 PF02771: Acyl-CoA_dh_N" amino acids 29 to 141 (113 residues), 134.3 bits, see alignment E=4.9e-43 PF02770: Acyl-CoA_dh_M" amino acids 145 to 236 (92 residues), 80.7 bits, see alignment E=1.4e-26 PF00441: Acyl-CoA_dh_1" amino acids 248 to 395 (148 residues), 125.8 bits, see alignment E=3.2e-40 PF08028: Acyl-CoA_dh_2" amino acids 263 to 380 (118 residues), 44.4 bits, see alignment E=4.1e-15

Best Hits

Swiss-Prot: 49% identical to GCDH_DICDI: Glutaryl-CoA dehydrogenase, mitochondrial (gcdh) from Dictyostelium discoideum

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 82% identity to mtt:Ftrac_1182)

MetaCyc: 55% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.7

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G1P4 at UniProt or InterPro

Protein Sequence (402 amino acids)

>Echvi_2990 Acyl-CoA dehydrogenases (Echinicola vietnamensis KMM 6221, DSM 17526)
MSSIQDHSASAKQDLFEGVDFYGLDDLFTAEHLLIRQSLRDFVKKEVSPYIEEWAQDAHF
PSEIVPKFGEIGAFGPQIPAKYGGGGLDYISYGLIMQEIERGDSGMRSTVSVQGSLVMYP
IHAFGSEEQREKFLPKLASGEWLGCFGLTEPDHGSNPGGLTTSFKDNGDHYLLNGAKMWI
SNAPEADIAVVWAKDENGRIHGLIVERGMEGFTTPTTHHKWSLRASCTGELVFDNVKVPK
ENLLPGKSGLSAPLMCLDAARYGIAWGAIGAAMDCYESAKRYAMERIQFDKPIAAFQLVQ
KKLAEMLTEITKAQLLAWRLGTLKDQGKATSAQISMAKRNNVAMALEIAREARQIHGGMG
ITGDYPIMRHMMNLESVITYEGTHDIHLLILGQEITGIPAFK