Protein Info for Echvi_2935 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 transmembrane" amino acids 6 to 22 (17 residues), see Phobius details amino acids 34 to 53 (20 residues), see Phobius details amino acids 93 to 117 (25 residues), see Phobius details amino acids 273 to 292 (20 residues), see Phobius details PF05569: Peptidase_M56" amino acids 171 to 263 (93 residues), 42.3 bits, see alignment E=2.8e-15

Best Hits

Predicted SEED Role

"Regulatory sensor-transducer, BlaR1/MecR1 family / TonB-dependent receptor" in subsystem Iron acquisition in Vibrio or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G1J2 at UniProt or InterPro

Protein Sequence (522 amino acids)

>Echvi_2935 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component (Echinicola vietnamensis KMM 6221, DSM 17526)
MIAYLIKSTISLLLCYLAYRLFLSKEKIHQFNRFFLLASIIFSLLAPLFHSPIRTSTEVA
HFSVMSNPQLTSEQTAPKKPRLSLPEKLPETAALPIAHILIGIYSIFLMYFLLRYAITIW
NFYRRTMTHQVIDRHGIKFVMDSCKDTPYTFFQYVFVNDTAYQKKQLDPRLLHHELVHAK
QWHSIDILLVELLKAIFWFNPIFHLYKKAIQLNHEFLADESVNRQFGNINAYQNLLLSYA
GQQQQNKLVSYSKHSLTKTRLIMMRKEKNLSNILLKLALIIPFILGGTFLFSMKPQRTTA
PKAIPQKVTPHPPSAPPQGDYLEEYKQHYQHLQELMDKKGKVNLNEIDIDRMRQLWDFMS
DKQKEKAPKVHGVPAPPIPEKKHASNYQMEEWTTNHDYGIWLDDTLVPNEELSGFSSKDI
AYWQYSRLYKNAKNYDKYKTRVSLMTHDGFYKTFIMKETGFDQLTAYNKAIEIYTAHQKH
PKKNAGQLGGKLSDLQQVYNHIPQWKKEKYEVKPPSEIIKNL