Protein Info for Echvi_2934 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 592 transmembrane" amino acids 37 to 57 (21 residues), see Phobius details amino acids 76 to 99 (24 residues), see Phobius details amino acids 149 to 173 (25 residues), see Phobius details amino acids 179 to 197 (19 residues), see Phobius details amino acids 261 to 284 (24 residues), see Phobius details amino acids 291 to 309 (19 residues), see Phobius details PF00664: ABC_membrane" amino acids 37 to 307 (271 residues), 156.8 bits, see alignment E=9.6e-50 PF00005: ABC_tran" amino acids 370 to 519 (150 residues), 110.5 bits, see alignment E=1.1e-35

Best Hits

KEGG orthology group: K11085, ATP-binding cassette, subfamily B, bacterial MsbA [EC: 3.6.3.-] (inferred from 76% identity to mtt:Ftrac_2492)

Predicted SEED Role

"Lipid A export ATP-binding/permease protein MsbA" in subsystem ZZ gjo need homes

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G0V0 at UniProt or InterPro

Protein Sequence (592 amino acids)

>Echvi_2934 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain (Echinicola vietnamensis KMM 6221, DSM 17526)
MKIAPIFICHMSTKKSERKVTIGHVFKTIIWPRRKQLFIGLFLIIISRLAGLVLPGASKY
LMDEVIPNSNMQLLKWLVIAVGVAVTVQAVTSFALTQILSVEAQHLIAKLRAKVQSHIIK
LPIRFFDNAKTGELVSRIMTDVEGVRNLVGTGLAQMVGGVLTSVICLGLLIYISPMMTLY
VLVPVIIFGLISLKAFGKIRPIFRERGKINAEVTGRLAETLGGIRVIKGFNAEAQEVKTF
EEGVLRLYLNIKSSLTTTSMVTSAATLLLGLASAGIMGIGGYMIMSGELTFGDFLAFTLY
LGFMIAPIVQMSNIGSQLTEAFAGLDRTEEIMNIPLEEDEKSRNLQLPSIKGDLAFEQVS
FAYEEGKNVVKEVSFEAPAGSMTALVGTSGSGKTTIAGLVASFLNPAGGTVTIDGTDLQQ
VSLASYRSQLGVVLQDDFLFEGTIRQNILFPRPDARTEQLMQAVYAAHVHEFTDRFEDGL
DTLIGERGVKLSGGQKQRIAIARAILADPRILILDEATSNLDTESETLIQESLKKLMKGR
TSFVIAHRLSTIRQADQILVVEKGEIVERGQHEELMEKRGRYFELYTYQARI