Protein Info for Echvi_2883 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: ATPase, P-type (transporting), HAD superfamily, subfamily IC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 809 transmembrane" amino acids 178 to 197 (20 residues), see Phobius details amino acids 215 to 235 (21 residues), see Phobius details amino acids 247 to 266 (20 residues), see Phobius details amino acids 272 to 292 (21 residues), see Phobius details amino acids 427 to 446 (20 residues), see Phobius details amino acids 456 to 477 (22 residues), see Phobius details amino acids 745 to 769 (25 residues), see Phobius details amino acids 775 to 797 (23 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 12 to 87 (76 residues), 53.1 bits, see alignment E=8.7e-18 PF00122: E1-E2_ATPase" amino acids 312 to 484 (173 residues), 123.2 bits, see alignment E=1.9e-39 TIGR01494: HAD ATPase, P-type, family IC" amino acids 315 to 525 (211 residues), 94.8 bits, see alignment E=2.1e-31 amino acids 598 to 772 (175 residues), 87.3 bits, see alignment E=4e-29 PF00702: Hydrolase" amino acids 506 to 703 (198 residues), 73.7 bits, see alignment E=5.3e-24

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 42% identity to cly:Celly_2047)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4); FUPA29 P-type ATPase" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G0Q3 at UniProt or InterPro

Protein Sequence (809 amino acids)

>Echvi_2883 ATPase, P-type (transporting), HAD superfamily, subfamily IC (Echinicola vietnamensis KMM 6221, DSM 17526)
MRQIDNRSFVLCYHCGEKCQEESLVFDEKDFCCPGCKLVYEVLQENDLSSYYEYGSRPGI
RQAVPHAPGNQFDYLNEPEVIQKLVDFSNDKESHITFHIPAIHCASCIWLLEHLHQLCNG
VFYSRTDFVKKECKVKFYTDRTSLREVVELLSKIGYPPTLNLSNVNPKKTSSKVDKRLIY
KLAVAGFCFGNMMFFSLPEYFSEVSLLEEEFRGLFGYLNLALSLPIVFYAATDYYRSAWY
ALKNGTVNMDVPIVMGIAALFFYSLHEVLGGGTGYLDSLGGLIFFLLIGKYYQQKTYDTL
SFDRDYAAYFPLAVTRMRQEGEEVISMPKLQVGDTIKVRKGELIPADSLLIQGDAQIDYS
FVTGEEVPVTVPKGSIIYAGGRQQAGALLLNVQKEPSQGYLTGLWNHESFKELPKEDLST
LANKISGKFTVAVLVIALVTFIFWSLNDLAMGVKAFSSVLIVACPCALALSTPFTLGNTL
RIMGHQKFFLKNGQVIERLAGITDYVFDKTGTLTDPTLANVMFIGEALSEDLKIAIKSMV
SESTHPLSHRINSWLPVYESVFIEGFQEQLGRGLEALYQGDIIRLGSPEWLGLGKVKSKE
GENRVYLAVNGKVLGYFHIMSTLRAGVEETIHELKNNGNVHVLSGDRATEAVKLKETLGA
DVMLNFHQSPMDKLKYLRRLDAEGKSTVMIGDGLNDAGALQASHVGIAVTDQSTYFSPAS
DAIMDVEALTKLPAFIGLARNGKQVIMASFVISLVYNVAGIGLAVQGLLSPVVCAVLMPL
SSISVVVFTTVMMNYFAYKKGLKTKWLWK