Protein Info for Echvi_2861 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: 6-phosphogluconate dehydrogenase, decarboxylating
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 54% identical to 6PGD_LACLA: 6-phosphogluconate dehydrogenase, decarboxylating (gnd) from Lactococcus lactis subsp. lactis (strain IL1403)
KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 70% identity to zpr:ZPR_2641)Predicted SEED Role
"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- pentose phosphate pathway (8/8 steps found)
- pentose phosphate pathway (oxidative branch) I (3/3 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Glutathione metabolism
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.44
Use Curated BLAST to search for 1.1.1.44
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0G2N8 at UniProt or InterPro
Protein Sequence (465 amino acids)
>Echvi_2861 6-phosphogluconate dehydrogenase, decarboxylating (Echinicola vietnamensis KMM 6221, DSM 17526) MKQFDFGIVGLGVMGKNLLLNMADHGFSVAGLDLDQAKAAALEEGAREGQDVKGFITAEK FVSSLKRPRAIMLLVPAGKPVDAAIGSLLPLLEKDDIVVDGGNSYFPDTERRFAELAKKN IHFFGMGISGGEKGARFGPSMMPGGDAQAYERLRPIFEAIAAKVDGEPCVTYLGKGSAGN YVKMVHNGIEYGIMQLIAETYDIMKKGLGYSDDKIQSIFASWNDTELQSFLVEITGLILQ KKDDDTGKQLLPLISDQARSKGTGKWTSQNAMDLQAPVPVIDMAVLMRDISKFKEERVAA SKALKWAGEENVDATADMLKNALYFGMITTYAQGMVQLRLASEEYGYGLNLEEVAKIWRG GCIIRAACLEDFRKAYKKAPDLANLMLDKEIGEDLVARQKDVREVVKVAVEKGIPAPALM AALSYFDAYRSDRLSTNVIQAQRDFFGAHQFERIDKEGVFHAQWE