Protein Info for Echvi_2480 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: valyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 877 TIGR00422: valine--tRNA ligase" amino acids 4 to 859 (856 residues), 942.1 bits, see alignment E=1.5e-287 PF00133: tRNA-synt_1" amino acids 15 to 574 (560 residues), 417.6 bits, see alignment E=1.3e-128 PF09334: tRNA-synt_1g" amino acids 44 to 189 (146 residues), 29.8 bits, see alignment E=6.7e-11 amino acids 352 to 415 (64 residues), 20.6 bits, see alignment 4.3e-08 PF13603: tRNA-synt_1_2" amino acids 242 to 303 (62 residues), 35 bits, see alignment 2.7e-12 PF08264: Anticodon_1" amino acids 617 to 755 (139 residues), 110.1 bits, see alignment E=2.3e-35 PF10458: Val_tRNA-synt_C" amino acids 812 to 876 (65 residues), 50.2 bits, see alignment 6.3e-17

Best Hits

Swiss-Prot: 62% identical to SYV_PARD8: Valine--tRNA ligase (valS) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K01873, valyl-tRNA synthetase [EC: 6.1.1.9] (inferred from 64% identity to cat:CA2559_07906)

Predicted SEED Role

"Valyl-tRNA synthetase (EC 6.1.1.9)" (EC 6.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FZJ4 at UniProt or InterPro

Protein Sequence (877 amino acids)

>Echvi_2480 valyl-tRNA synthetase (Echinicola vietnamensis KMM 6221, DSM 17526)
MSLSTKYNPAEAESKWYAFWMENKLFSSKVDYNKEPYSIVIPPPNVTGVLHMGHMLNNTI
QDVLVRKARMEGKNACWVPGTDHASIATEAKVVALLKEKGIDKKSISREDFLTHAWEWKE
KYGGIILEQLKKLGASCDWDRTKFTMDAGLSDAVTSVFVDLHNKGKIYRGIRMVNWDPQG
KTALSDDEVIFKEVQSKLYYINYKIEGSETEYLTVATTRPETIMADVAICINPNDKRFAH
LKGKKALIPLINRAIPIVEDDYVDMEFGTGCLKVTPAHDVNDYEIGLRHKLEVIDIINDD
GTLNEKAQILVGEDRFIARKKIAKLLKEAGQLQKEEDYLSNVGHSERTDAVIEPKLSLQW
FLKMEDITKPALKAVMDDIIQLYPPKFKNMYRSWMENVRDWCISRQLWWGHQIPAFYLPN
GEYVVAKTAEEALEIANDKYNENYGLNDLTQDEDVLDTWFSSWLWPISVFDTDVFTTGKK
NEELSYYYPTNDLVTAPEILFFWVARMIIAGYEYMGEKPFRNVYLTGIVRDKQGRKMSKS
LGNSPDPLELIKNYGADGVRTGMLFSSPAGNDLPFDEKLVEQGRNFANKIWNAFRLIKGW
EVDSNILEHHNHTAINWFESRFDQALEEIEDHFSKFRISDALMSTYKLVWDDFCSWYLEM
VKPEYQKPIDLETYEKTLGYFEAIMKILHPFMPFITEELWHQVKGRDVKDALIISSWPSK
GAYDVKLINDAAQVFEVVSQVRNIRASKGISPKEAFDLTINTKNKELYTSFGAILKKLAN
LSQMEFAEKVDGALSFVVKSDEFFIPLNEQIDVEAEKENIQKELEYTKGFLNSVTKKLSN
ERFVNNAPAQVVENEKKKQADAEAKIKALEESLAKLV