Protein Info for Echvi_2422 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 PF00072: Response_reg" amino acids 9 to 123 (115 residues), 70.1 bits, see alignment E=6.3e-23 PF00158: Sigma54_activat" amino acids 157 to 323 (167 residues), 225 bits, see alignment E=1.6e-70 PF14532: Sigma54_activ_2" amino acids 158 to 328 (171 residues), 74.2 bits, see alignment E=4.4e-24 PF07728: AAA_5" amino acids 180 to 298 (119 residues), 26 bits, see alignment E=2.8e-09 PF00004: AAA" amino acids 181 to 304 (124 residues), 21.5 bits, see alignment E=9.4e-08 PF02954: HTH_8" amino acids 418 to 458 (41 residues), 58.5 bits, see alignment 1.5e-19

Best Hits

Swiss-Prot: 38% identical to ALGB_PSEAE: Alginate biosynthesis transcriptional regulatory protein AlgB (algB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 70% identity to mtt:Ftrac_1849)

Predicted SEED Role

"Two-component system response regulator" in subsystem Streptococcal Mga Regulon or Two-component regulatory systems in Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FXN3 at UniProt or InterPro

Protein Sequence (460 amino acids)

>Echvi_2422 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains (Echinicola vietnamensis KMM 6221, DSM 17526)
MEDTSLGKILIVDDNEDLLFAAKMLLKKYAKEVTIEKDPRRIPFLVNNNNYDVILLDMNF
TEDTTSGKEGFHWLKQIKEIDPKAVVILITAFGDVEMAVQALKEGATDFILKPWQNEKLL
ATLSAASRLKESYDQVDNISQKSRQLQADMKKPFSEIIGQSSSMKNIFSIIDKVAQTDAN
VLILGENGTGKELIARAIHDRSLRRDEIFVGVDMGAITETLFESELFGHKRGAFTDAKED
RAGRFEVADKGTLFLDEIGNLSMPLQSKLLTVLQKREVTRIGTNKSIPVDIRLICATNMK
VHDMVMENTFRQDLLYRVNTVEIFLPPLRERQDDIPLLANHFLKVYAKKYRKDFSGFKPA
AIQLLQNYSWPGNIRELQHAIERAIIMAEGQELDSRDFFFLSSKPSAEKVKTNGTLNLDE
VEKNVIQKAIDKNGGNISKAAKELGLTRASLYRRLEKYGL