Protein Info for Echvi_2366 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: chaperonin GroL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 543 TIGR02348: chaperonin GroL" amino acids 2 to 526 (525 residues), 874.5 bits, see alignment E=1.2e-267 PF00118: Cpn60_TCP1" amino acids 22 to 522 (501 residues), 294.4 bits, see alignment E=8.2e-92

Best Hits

Swiss-Prot: 81% identical to CH60_CYTH3: 60 kDa chaperonin (groL) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K04077, chaperonin GroEL (inferred from 81% identity to chu:CHU_1828)

MetaCyc: 66% identical to chaperonin GroEL (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Heat shock protein 60 family chaperone GroEL" in subsystem GroEL GroES or Staphylococcal pathogenicity islands SaPI

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FXJ1 at UniProt or InterPro

Protein Sequence (543 amino acids)

>Echvi_2366 chaperonin GroL (Echinicola vietnamensis KMM 6221, DSM 17526)
MAKELFFDTDAREKLKKGVDALAEAVKVTLGPKGRNVIIDKKFGAPTITKDGVSVAKEIE
LEEPIENMGAQLVKEVASKTADNAGDGTTTATVLTQSIFNVGIKNVAAGANPMDLKRGID
KAVAAVVAELKATSKPISTSKEIAQVGTISANNDEEIGNMIADAMDKVGKDGVITVEEAK
GTETEVKTVEGMQFDRGYLSPYFTTNTEKMEAELENPYILIYDKKISSMKELLPVLEPVA
QSGKPLLIIAEDVDGEALATLVVNKIRGALKVAAVKAPGFGDRRKAMLEDIAILTGGTVI
SEERGYKLENASIEYLGTAEKVNIDKDNTTIVNGAGEKSTIEARISEIKTQIEKTTSDYD
KEKLQERLAKLSGGVAILYIGAATEVEMKEKKDRVDDALHATRAAVQEGVVVGGGVALIR
ASSALDGLKGENDDQDTGINIIKQAIESPLRSIVANAGAEGSVVINKIKEGTGNYGYNAR
TDKFEDLFEAGVIDPTKVTRLALENAASIAALLLTTECVVADVKEEGGQPAPPMGGGGMG
GMM