Protein Info for Echvi_2305 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Protease II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 690 PF02897: Peptidase_S9_N" amino acids 17 to 407 (391 residues), 379.8 bits, see alignment E=1.5e-117 PF00326: Peptidase_S9" amino acids 468 to 681 (214 residues), 222.4 bits, see alignment E=4.9e-70

Best Hits

Swiss-Prot: 43% identical to PTRB_MORLA: Protease 2 (ptrB) from Moraxella lacunata

KEGG orthology group: K01354, oligopeptidase B [EC: 3.4.21.83] (inferred from 60% identity to zpr:ZPR_2342)

Predicted SEED Role

"Protease II (EC 3.4.21.83)" (EC 3.4.21.83)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.83

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FZW5 at UniProt or InterPro

Protein Sequence (690 amino acids)

>Echvi_2305 Protease II (Echinicola vietnamensis KMM 6221, DSM 17526)
MKAIKAPKAPIKIQDITYHEHTRRDPYYWMNERENPEVIQYLNEENAFLKASLAHTEPLQ
EKLYQEMKNRIKEDDESVPYFRDGYYYYTKFVKGGEYPVFCRKEGSLQHPEEILLDVNLL
AKEHDYFNVNAVTLSYNQQLLAHAEDHVGRRVYNIKIKDLSTGSALPDQITEVTGNMVWA
NDNKTLFYSKQDPNTLRAYQIYQHTLGTPQEEDILVYEEADETFTCHVAKSKSKDYIFIV
SESTVSSEIRYLDAHHPTSPFHLIQERERDLEYSVEHFEDHFLILTNHQHAKNYKLVKAP
TKNPDKSQWVDIIAHRDDTLLEGFEVFGQFLVLEERSNGLTKIQIIPLDGSDHHYITFDD
PTYAAWLGYNPQFDTTTLRFGYNSLTTPSSTYDYDMVRREKVLLKQQEVQGGFDPSLYQS
ERIWATAQDGTKIPISLVYKTATFKKDGSNPLLQYAYGSYGFSTDPVFSSSRLSLLDRGF
VFAIAHIRGGQELGRHWYDDGKMLKKRNTFTDFITCSEHLLRESYTSLGKLFAMGGSAGG
MLMGTIINMRPDLYEGVIAAVPFVDVVTTMLDESIPLTTGEFDEWGNPKNKEYYDYMLSY
SPYDNVEKKEYPHLLVTSGLHDSQVQYWEPTKWVAKLRVEKTDKNMLLLYTNMDAGHGGA
SGRFHALKETAMEYAFLLDLAEKGQNQPPE