Protein Info for Echvi_2227 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Predicted signal-transduction protein containing cAMP-binding and CBS domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 PF00027: cNMP_binding" amino acids 26 to 115 (90 residues), 28.8 bits, see alignment E=1.9e-10 PF00571: CBS" amino acids 167 to 212 (46 residues), 20 bits, see alignment 1.5e-07 amino acids 226 to 278 (53 residues), 25.7 bits, see alignment 2.4e-09 PF03445: DUF294" amino acids 305 to 443 (139 residues), 150 bits, see alignment E=8e-48 PF10335: DUF294_C" amino acids 482 to 622 (141 residues), 118.4 bits, see alignment E=4.6e-38

Best Hits

KEGG orthology group: K07182, CBS domain-containing protein (inferred from 52% identity to psn:Pedsa_1073)

Predicted SEED Role

"Predicted signal-transduction protein containing cAMP-binding and CBS domains" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FYV5 at UniProt or InterPro

Protein Sequence (629 amino acids)

>Echvi_2227 Predicted signal-transduction protein containing cAMP-binding and CBS domains (Echinicola vietnamensis KMM 6221, DSM 17526)
MVDFTKPFSDLPPTAQDSLRQQFKEVKYPKSRRLYLQNQSGIEGFDFIAEGGFEGYFYDR
NQKKRRIEQYGPGTWFGGISLLYNKGISLQTVDILPKTVIYRLTPEEFATLCEEHPLFRD
HFVREFGERMLEPEFVHFIKGATYYPQQNNITSDTFYTQKVGSLNPRDLITSPATASIAA
TAKIMGEEKTSCIFITDDTDNIIGYVTDITLRDQVIAQNIPPSSPVETITKKDIVSIDAD
AYIYESLLLMFQTKTRYLLVVNDGKFSGFISRTKLLSEQSQSPFLFIQSVKQATSVKELR
EKWSQVPAIVEQLLQRGVKSETVNQVITTVSDTIALRVIDDVIHEVGPPPSRFVFITLGS
EGRKEQTLKTDQDNAIIYEDKANEHREEVRAYFLDFADRISTHLDTIGFSFCKGGFMAKN
PKWTHSLSHWKRNYDSWMMESTQETVMKYSTFFDNRPIYGDFSILNELHDYMEEQLNAPL
ERFFFNMATNALQYEPPLTFFKGIRTFTVGEQKVFDIKKAMTPIVDITRVFALKHKIFLT
NTGERLDALALANHITEEELLELKQAYYYLMGLRLDRQAKQIMLDKTEPENFISIDSLTK
IEKVTLIEIFKVIKNYQMKVKIAFTNTIF