Protein Info for Echvi_2112 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1242 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 210 to 231 (22 residues), see Phobius details amino acids 242 to 262 (21 residues), see Phobius details amino acids 289 to 307 (19 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details amino acids 368 to 396 (29 residues), see Phobius details amino acids 405 to 424 (20 residues), see Phobius details amino acids 426 to 447 (22 residues), see Phobius details amino acids 457 to 478 (22 residues), see Phobius details amino acids 722 to 748 (27 residues), see Phobius details amino acids 767 to 787 (21 residues), see Phobius details amino acids 927 to 953 (27 residues), see Phobius details PF00512: HisKA" amino acids 1017 to 1084 (68 residues), 31.9 bits, see alignment 1.1e-11 PF02518: HATPase_c" amino acids 1127 to 1233 (107 residues), 79.5 bits, see alignment E=2.7e-26

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FZ80 at UniProt or InterPro

Protein Sequence (1242 amino acids)

>Echvi_2112 His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (Echinicola vietnamensis KMM 6221, DSM 17526)
MLKKRRLIIVFGIILMAIVLAINFFSGSPDESKAGLEQIETTTRKVAEEFDEDFIQLLMN
YRPEKQMSFSTLNFDSKHPFYLYTSDGQLLYWSSVSMIPDFKDVDTGASFKPYQLIDNSK
GTYFSRVRSINRNNQQYWMVQVYSLYDKVEIDNEYLHAGYNNDVFGNDRFILSAEPRGEY
DKVTGNRGEYFFSVSLRMGYVPVGHKSSTALLLFFFSLTGLVFILGGDFVVRLWSHGRRK
LALLYTISILVSIRAIMLVFHFPQDYFEVPLFDATYYASSILNPSLGDLLLNVIFSAIVL
AMLISMLGRREVIVAFAKIRKRYYQWVFYLIAYLLSGFFLFLFFKLFTNISNNSQWNLNI
LDIPTFDYFKAISILILFVGGAGYLMFTLMSLNLVFYKARAKKAYALKVLMGLSLPILLV
TAWFDFIYLVVYISHIILLVAIISFELYDNVLKLQLNTFLTFFFGCLVGAVVTGAASYQD
YGKREIHEKERLANQILREKDVMAEFLLSDVMQRVKEDLFIKNRMTNPSLSKDPVEQKIR
KIYISNYFDQYELNIMIFSPSGEDVLDRSNEQSLDDLRYRYMNSDYATSVRNLYFVKSGE
GVEGNKFYAFMPMVKDGDFIGTIVMELVQQRIKSTSVFPKLLLDKKYIDDIYDSNLDYAL
FRDSVLQYSIGVYNYRNPDVIELLENNNLYKSGMNRDGYHHFGVRNGSSTLIVSSPIYPY
NYILADVSFFFISYIACTLFFIIIYALLNGLNKVQFNYATRLQFHLNFAFFVPMLVISAI
SIGLLSKSYLEDLHRQYFEKANIIRDNLFQYLEQETKGVMDRDEFLAEVYRLANTTATDI
NVFSSDGKLMATSQPNIIEKKVLTRYLNPEAYAEIIEAQNNQVILDEQVGSLKYKTVYIS
LREMKRQHTLGIISIPFFESEEELNVLIVDVFSTIINIFVAIFIVFLIVSYFVSKQLTDP
FKLLTQKLKVTNLEDNEPMYWPTNDEIGLLVKEYNNMLYKLEASRKTLSLTEKESAWREM
AKQVAHEIKNPLTPMKLTLQHLLRLQAEGRIDDPEKLKKPIHNMINQVDTLSDIATSFST
FAKMPLPKNELMDFEQVVINAVELFKNNERGKVVFYDQVQERLPVMGDDKLFGRVISNLI
INGLQSVPEDRVPTVTVTLTTQKEWTRLEVKDNGAGIPEEFRDKIFIPNFSTKSEGSGLG
LAIAKRGVETAGGNIWFETVVGEGTSFYLTFPLVKMAKPGAS