Protein Info for Echvi_2069 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to CCSD_UNKP: Cysteine/Cysteine sulfinic acid decarboxylase (undec1A) from Unknown prokaryotic organism
KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 57% identity to hhy:Halhy_2725)Predicted SEED Role
"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)
MetaCyc Pathways
- superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
- superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
- coenzyme A biosynthesis I (bacteria) (4/4 steps found)
- coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
- coenzyme A biosynthesis III (archaea) (3/4 steps found)
- taurine biosynthesis II (1/4 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.36 or 6.3.2.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FZY4 at UniProt or InterPro
Protein Sequence (399 amino acids)
>Echvi_2069 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic (Echinicola vietnamensis KMM 6221, DSM 17526) MQLQGKRILLGITGSIAAYKAAHLTRLLVKEGAEVQIIMSTSALDFITPLTLSTLSKKPV YHRFHKDDTGEWNNHVELGLWADLFIIAPLSASTLSKLAHGNSDNLLVATYLSARCPVML APAMDLDMYQHPAVTSNLYLVQTFGNILLDAESGELASGLSGQGRMREPEHIVEKVISHF HTSSDLKDQTALVTAGPTQEAIDPVRYIGNHSSGKMGVAIAENMANRGAKVTLVMGPSHE KSHHPNITTVHVTSAQDMFEAAQKAHPHAKISVFAAAVADYAPAVQAQEKIKKSTDDLSI LLKKNIDIAKTLGKEKSEDQYHVGFALETNQEEKHALAKLKEKNFDFIVLNSMQDKGAGF KHDTNKITIYHKSGKSDASPLLPKSAVAALIVDHIVKDL