Protein Info for Echvi_2021 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: trehalose-phosphatase/alpha,alpha-trehalose-phosphate synthase [UDP-forming]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 722 PF00982: Glyco_transf_20" amino acids 3 to 460 (458 residues), 547.8 bits, see alignment E=4.5e-168 TIGR02400: alpha,alpha-trehalose-phosphate synthase (UDP-forming)" amino acids 5 to 460 (456 residues), 594.1 bits, see alignment E=2.6e-182 TIGR00685: trehalose-phosphatase" amino acids 489 to 721 (233 residues), 125.9 bits, see alignment E=3.6e-40 TIGR01484: HAD hydrolase, family IIB" amino acids 493 to 689 (197 residues), 80.5 bits, see alignment E=2.8e-26 PF02358: Trehalose_PPase" amino acids 495 to 692 (198 residues), 169.4 bits, see alignment E=1.5e-53

Best Hits

KEGG orthology group: K00697, alpha,alpha-trehalose-phosphate synthase (UDP-forming) [EC: 2.4.1.15] (inferred from 54% identity to mtt:Ftrac_2520)

Predicted SEED Role

"Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15) / Trehalose-6-phosphate phosphatase (EC 3.1.3.12)" in subsystem Trehalose Biosynthesis (EC 2.4.1.15, EC 3.1.3.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.15 or 3.1.3.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWI8 at UniProt or InterPro

Protein Sequence (722 amino acids)

>Echvi_2021 trehalose-phosphatase/alpha,alpha-trehalose-phosphate synthase [UDP-forming] (Echinicola vietnamensis KMM 6221, DSM 17526)
MGKTIIVSNRLPVSLRHKNGKFEFKPSAGGLATGLGSIYKEGENIWIGWPGNDVEDPEQR
AEIIIELHELKMAPVFLTREDIEQFYEGFSNETLWPAFHYFTQNINYDEHHWEAYVRVNK
MFCDAILKKADPDDTIWVHDYQLLLLPQMLREKLPNATIAFFQHIPFPSYEVVRMLPWRH
EILAGMCGADLIGFHTYDDMRHFLSAVGRIMGLSNESGYIQAENRLINVDSFPMGIDYDK
FAKSAKSKKTQTIAKKFLELLGDQKLLLSIDRLDYSKGIPKRIKAFDRFLEENPEYHGKV
SMIMVVVPSRDKVRSYQRLKEDIDTLVGRINSDYSTLNWVPIHYFYRSFPFEELSAFYAM
SDIALVTPLRDGMNLVCKEFVASKVNKKGVLILSEMAGASKELQDAILVNPNNNKGVADA
IKQAITMPEKEQQARIVSMQETIQRYDVFQWVKVFMDRLQYVKQKQLDLQSKEVDADVIS
ELHENFKKAKKPILFLDYDGTLVGFKGKPEEASPDEELKSLVSKLTKKSQVVIISGRDKE
TLGKWFKGQKVDIIAEHGVWLKINGGKDWELYADIDDHWKPDIKSVMEYYVQRTPGAHIE
EKHHSLVWHYRKVESGLGDLRMRELFSHLKYMARGHNLQVLEGNKVLEIKRPDINKGRAA
SAFMKGNEYDFILAIGDDWTDEDTFQAMPENAFSIRVGYSYTKANYNIKSPKEVRYLLNK
LT