Protein Info for Echvi_1798 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Uridine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01048: PNP_UDP_1
  • amino acids 32 to 261 (230 residues), 80.5 bits, E=6.2e-27

Best Hits

KEGG orthology group: K00757, uridine phosphorylase [EC: 2.4.2.3] (inferred from 54% identity to mtt:Ftrac_3591)

Predicted SEED Role

"Purine nucleoside phosphorylase (EC 2.4.2.1)" in subsystem Adenosyl nucleosidases or Deoxyribose and Deoxynucleoside Catabolism or Purine conversions (EC 2.4.2.1)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (12/14 steps found)
• pyrimidine deoxyribonucleosides degradation (3/3 steps found)
• guanine and guanosine salvage I (2/2 steps found)
• pyrimidine ribonucleosides degradation (2/2 steps found)
• xanthine and xanthosine salvage (2/2 steps found)
• adenine and adenosine salvage III (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine deoxyribonucleosides degradation I (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• purine deoxyribonucleosides degradation II (2/3 steps found)
• superpathway of guanine and guanosine salvage (2/3 steps found)
• purine ribonucleosides degradation (4/6 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (4/6 steps found)
• adenine and adenosine salvage I (1/2 steps found)
• superpathway of purine deoxyribonucleosides degradation (4/7 steps found)
• adenine and adenosine salvage V (1/3 steps found)
• adenosine nucleotides degradation II (2/5 steps found)
• superpathway of pyrimidine ribonucleosides degradation (2/5 steps found)
• ureide biosynthesis (3/7 steps found)
• nucleoside and nucleotide degradation (archaea) (5/10 steps found)
• fluoroacetate and fluorothreonine biosynthesis (1/6 steps found)
• nucleoside and nucleotide degradation (halobacteria) (1/6 steps found)
• arsenic detoxification (mammals) (7/17 steps found)
• salinosporamide A biosynthesis (4/15 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.1

Use Curated BLAST to search for 2.4.2.1 or 2.4.2.3

Sequence Analysis Tools

See L0FXP8 at UniProt or InterPro

Protein Sequence (287 amino acids)

>Echvi_1798 Uridine phosphorylase (Echinicola vietnamensis KMM 6221, DSM 17526)
MTKVIPASELIINPDGSIYHLNLKPEFLASNVITVGDPERVPKISQYFDHVDIKVAKREF
VTHTGTYKGKRLSVMSTGMGTDNIEIFMTELDALVNIDLQTRQVKPKHTALNIVRVGTSG
SMREEIPAGALVASEYAVGLDTLMQYYAADYSDKEQAIREAVQQSLGVDFLPYCFEGSKK
LLGQMNTKDMILGNTATCPGFFGPQGREVRLKPAIPDIIERLSAMEVDGFQLTNFEMETA
GYYAMGKMLGHEVLSLNAIVANRITHTFVGNPSEVVDHLIHHTLEHI