Protein Info for Echvi_1629 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Protease subunit of ATP-dependent Clp proteases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 transmembrane" amino acids 35 to 57 (23 residues), see Phobius details amino acids 66 to 84 (19 residues), see Phobius details amino acids 90 to 111 (22 residues), see Phobius details PF00574: CLP_protease" amino acids 22 to 197 (176 residues), 202.8 bits, see alignment E=2.3e-64

Best Hits

Swiss-Prot: 56% identical to CLPP_DEHMC: ATP-dependent Clp protease proteolytic subunit (clpP) from Dehalococcoides mccartyi (strain CBDB1)

KEGG orthology group: K01358, ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] (inferred from 64% identity to hhy:Halhy_1532)

MetaCyc: 45% identical to ATP-dependent Clp protease proteolytic subunit (Escherichia coli K-12 substr. MG1655)
Endopeptidase Clp. [EC: 3.4.21.92]

Predicted SEED Role

"ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent or cAMP signaling in bacteria (EC 3.4.21.92)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.92

Use Curated BLAST to search for 3.4.21.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FVG7 at UniProt or InterPro

Protein Sequence (219 amino acids)

>Echvi_1629 Protease subunit of ATP-dependent Clp proteases (Echinicola vietnamensis KMM 6221, DSM 17526)
MISANASQVVPMVIDQNDYSGRAYNIFSLLLKERIIFLGSAINDQVANLVVAQLLFLNSQ
DTKRPISLYIQSPGGSVYAGMAIYDTIQMISAPVITLAVGFTGSMATALLTSGAKGKRQA
LSHATIHMHPTSGGSKGYTEDVRIATKEQERLQVQLFHIIGNNIGHKWQEIEELFLRDRY
MSAPEAKEYGLVDEVLGNTTDIVQLQNMPFGVRFYEDVS