Protein Info for Echvi_1448 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: 3-hydroxyanthranilate 3,4-dioxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06052: 3-HAO
  • amino acids 2 to 152 (151 residues), 207.5 bits, E=8e-66
• TIGR03037: 3-hydroxyanthranilate 3,4-dioxygenase
  • amino acids 7 to 166 (160 residues), 245.7 bits, E=1e-77
• PF07883: Cupin_2
  • amino acids 44 to 101 (58 residues), 31.1 bits, E=1.5e-11

Best Hits

Swiss-Prot: 55% identical to 3HAO_XANAC: 3-hydroxyanthranilate 3,4-dioxygenase (nbaC) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K00452, 3-hydroxyanthranilate 3,4-dioxygenase [EC: 1.13.11.6] (inferred from 69% identity to chu:CHU_3382)

MetaCyc: 44% identical to 3-hydroxyanthranilate 3,4-dioxygenase (Geobacillus thermodenitrificans NG80-2)
3-hydroxyanthranilate 3,4-dioxygenase. [EC: 1.13.11.6]

Predicted SEED Role

"3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6)" in subsystem NAD and NADP cofactor biosynthesis global or Quinolinic acid and its derivatives (EC 1.13.11.6)

MetaCyc Pathways

• NAD de novo biosynthesis II (from tryptophan) (8/9 steps found)
• NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde (4/4 steps found)
• superpathway of NAD biosynthesis in eukaryotes (11/14 steps found)
• L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde (4/5 steps found)
• L-tryptophan degradation III (eukaryotic) (7/15 steps found)
• 2-nitrobenzoate degradation I (1/7 steps found)
• L-tryptophan degradation IX (4/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (3/12 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (8/23 steps found)

KEGG Metabolic Maps

• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.13.11.6

Sequence Analysis Tools

See L0FUZ0 at UniProt or InterPro

Protein Sequence (170 amino acids)

>Echvi_1448 3-hydroxyanthranilate 3,4-dioxygenase (Echinicola vietnamensis KMM 6221, DSM 17526)
MALTKPFNFKQWIEDNRHLLKPPVGNQQVYKGNDDFIVMVVGGPNSRKDYHYNEGEEFFY
QLEGDIVLKVIEEGKPKDIEIKEGEIFLLPPKVHHSPRRPANTVGLVMERYRKEGEKDGF
IWYCENCGNKLYEEYAVVTDIVSQLPPIMERFWSNPENTTCQSCGTKMEK