Protein Info for Echvi_1312 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: transcription-repair coupling factor (mfd)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1116 PF17757: UvrB_inter" amino acids 148 to 231 (84 residues), 78 bits, see alignment 1.5e-25 TIGR00580: transcription-repair coupling factor" amino acids 241 to 1046 (806 residues), 934.2 bits, see alignment E=5.2e-285 PF02559: CarD_TRCF_RID" amino acids 437 to 493 (57 residues), 57.8 bits, see alignment 2.9e-19 PF00270: DEAD" amino acids 582 to 722 (141 residues), 84.4 bits, see alignment E=2.3e-27 PF04851: ResIII" amino acids 587 to 718 (132 residues), 32.2 bits, see alignment E=3.1e-11 PF00271: Helicase_C" amino acids 762 to 866 (105 residues), 70.6 bits, see alignment E=4e-23 PF03461: TRCF" amino acids 975 to 1065 (91 residues), 86.7 bits, see alignment E=3.4e-28

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 62% identity to chu:CHU_3453)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FX35 at UniProt or InterPro

Protein Sequence (1116 amino acids)

>Echvi_1312 transcription-repair coupling factor (mfd) (Echinicola vietnamensis KMM 6221, DSM 17526)
MEKHAFLTLYEQDSYIKTVAKTIQSSVGSNFAFKGISGSMDMVLLATFINLRHSSHLIIA
HDKEEAAYLASDLSSLLDRVTPHIFPSSYKRPYQHEEVDNANVLMRAEILNKVLSSDTKM
EIIVSYPEALYEKVINKKSLQENTFTAKVGEKVDVEFITELLSTYDFEKTDFVYEPGQFA
IRGGIIDVFSFANEYPYRIELFGKEIESIRTFDTESQLSEESLDHISIIPNVQTKLMQEV
RQSFTDFLPKDTCVWIKDVQFTMDMLDNAFEKARQQFDKIVDQTGSKQLVLQPENLFDDG
AAFLSSLDRLTKIEFGNQYHLPTSKVFDFDIKPQPSFNKNFDLLVENLVDNERKGLLNII
CSESEKQVERLQNIFQELDPTLKIQSLPVSIREGFVDHSTMIACYTDHQIFERYHRYKSH
KKASKTKALTLKELKTLQAGDYVVHVDYGVGRFAGLEKVEVNDNFQEAVRLIFRDDDLLY
VNIHSLHKISKYSGQEGTLPTMSKLGSPEWENKKKKVKRKVKDIAKDLIALYAKRRNASG
HQYAPDSVLQVELESSFIFEDTPDQAVATGDVKADMEKPYPMDRLVCGDVGFGKTEVAIR
AAFKAINDRKQVAVLVPTTILAMQHYRTFKERLEGFPVKVDYINRFRTTKQVKEITKQVT
SGEIDILVGTHRIVNKDVQFKDLGLLIIDEEQKFGVKVKDQLKELRVNVDVLTLTATPIP
RTLHFSLMGARDLSVIATPPPNRQPVTTEIHTFEEEVIRDAVSRELQRGGQVFFVHNRVG
EIDSIANLIMRLVPDAKIAGAHGQMDGKQLEKIMVKFIEGEFDVLVSTNIIESGLDIPNA
NTIIINRAHMFGLSDLHQMRGRVGRSNKKAYCYLLTSPMSGLTAEARKRLQTLEEFSDLG
DGFKVAMRDLDIRGAGNLLGAEQSGFITDLGFEMYHKILDEAVQELKENEFASLFEVDLK
EKVKVLVQDCVIETDMELLIPEDYVSNISERLNLYSKLDNIKTEEALTKFAHAVSDRFGP
IPPVVEDLMETVRLRWLAEGLGFEKLVLKSGQMKCYFVPSTRESYFKSDIFGNIIRFIQG
HGKFCKIKEHKNRLILTIGGIKSVEKAKQWLSEMSA