Protein Info for Echvi_1293 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 559 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 299 to 321 (23 residues), see Phobius details PF00512: HisKA" amino acids 334 to 399 (66 residues), 45.8 bits, see alignment E=7.5e-16 PF02518: HATPase_c" amino acids 448 to 558 (111 residues), 92.8 bits, see alignment E=2.9e-30 PF14501: HATPase_c_5" amino acids 451 to 544 (94 residues), 26.4 bits, see alignment E=8.2e-10

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FUL0 at UniProt or InterPro

Protein Sequence (559 amino acids)

>Echvi_1293 His Kinase A (phosphoacceptor) domain./Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (Echinicola vietnamensis KMM 6221, DSM 17526)
MSLACLGLVGFQYYWVANAIKINQERFEQNVYQSLAASITKLEKGETSDIILSTMAKDST
FKQMLFQKIEPIEVNIRRRLSFEGRPSVMDSVFKEPLPKVSSTFERIIASRGGKPEDKFE
LQKYFELPASVARQLFTPDEMAIYLKEKEKYLEFVSRRDSFVQAQDYLMNRKAIITEEYD
ISEDVAENIIKANKKIELMQVVFTQLLADTQENILYRVDTTELHRDISSQLKKRGISGEF
ELAILNNKGRLIPINRISDPMEFRKNSIRAELFPGDLVGQDNFMVIHFPKKQLYLLKQIW
LPLSSSLLFLLIIILCFVYAIKVIIRQKKLSETKNDFINNMTHEFKTPIATVSLAVEALQ
DPELINQDTFRNRYLGIIKDENKRLGSQVEKVLQAAALDKKDFKLKFEQVNIVDLIKDAK
KHFDLQVEKKGGRILLDIDVKDPYLEADAFHLSNIINNLLDNANKYSADKPHIALKVKEM
ATGFSITIKDNGMGMSKDSVKKIFEKFYRVPTGNVHDVKGFGLGLAYVKTMVEEHNGSIS
VESEINKGSTFTITLPRKK