Protein Info for Echvi_1215 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: excinuclease ABC, B subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 TIGR00631: excinuclease ABC subunit B" amino acids 3 to 664 (662 residues), 1016.4 bits, see alignment E=0 PF04851: ResIII" amino acids 11 to 85 (75 residues), 45.2 bits, see alignment E=2.5e-15 PF17757: UvrB_inter" amino acids 158 to 247 (90 residues), 106.2 bits, see alignment E=1.9e-34 PF00271: Helicase_C" amino acids 430 to 543 (114 residues), 72.7 bits, see alignment E=7.5e-24 PF12344: UvrB" amino acids 550 to 590 (41 residues), 82.7 bits, see alignment 3.3e-27 PF02151: UVR" amino acids 635 to 663 (29 residues), 26.3 bits, see alignment (E = 1.2e-09)

Best Hits

Swiss-Prot: 75% identical to UVRB_CYTH3: UvrABC system protein B (uvrB) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K03702, excinuclease ABC subunit B (inferred from 78% identity to mtt:Ftrac_2586)

MetaCyc: 59% identical to UvrABC excision nuclease subunit B (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit B" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FXK5 at UniProt or InterPro

Protein Sequence (678 amino acids)

>Echvi_1215 excinuclease ABC, B subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MDFKIISDYSPTGDQPNAIKNLSEGISSGEPSQVLLGVTGSGKTFTVANVIQEVQRPTLV
LCHNKTLAAQLYGEFKQFFPDNAVEYFISYYDYYQPEAFIPTSGVYIEKDLSINEEIEKL
RLSATSALLSGRRDVIVVASVSCIYGIGNPEEFGKNVVNLEEGQRIPRNQLLFQLVDILY
SRANVEFKHGTFRVKGDTVDIFVAYADFAYRIYFWGDEIEGIQRIDPETGKRISSEKQIT
IFPANLFVTGKETIDVAIKEIQDDLMSQISFFEKDMRLEEASRLRERTEFDLEMIRELGY
CSGVENYSRYFDRRSAGARPFCLLDYFPDDYMLVIDESHVTVPQIRAMWGGDRSRKVNLV
EYGFRLPSALDNRPLKFDEFESLTNQVIYVSATPADYELNQTDGVVVEQIIRPTGLLDPL
IEVRPSGDQIDDLLEEIDQTIKKGDRVLVTTLTKRMAEELNKFLERAGIKSRYIHSEVKS
LDRVEILRELRLGIFDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNERSLVQTIGRA
ARNENGRVIMYADRVTASMQRAIDETKRRRSIQMAYNEEHGITPKTVIKSKDKIMGQTKV
ADSKKNAKFYDDHFTEENAYAADPVVQYLSKEKLEKLIPQTQKQMEKAAKELNFMEAARL
RDEWQGQKKRLEELKRMD