Protein Info for Echvi_1212 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Acyl-CoA dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 379 PF02771: Acyl-CoA_dh_N" amino acids 6 to 118 (113 residues), 121.5 bits, see alignment E=4.5e-39 PF02770: Acyl-CoA_dh_M" amino acids 122 to 217 (96 residues), 100 bits, see alignment E=1.3e-32 PF00441: Acyl-CoA_dh_1" amino acids 231 to 378 (148 residues), 184.3 bits, see alignment E=3.3e-58 PF08028: Acyl-CoA_dh_2" amino acids 244 to 366 (123 residues), 95.9 bits, see alignment E=5e-31

Best Hits

Swiss-Prot: 56% identical to ACDA_BACSU: Acyl-CoA dehydrogenase (acdA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 80% identity to mtt:Ftrac_2045)

MetaCyc: 52% identical to Bcd (Clostridium acetobutylicum ATCC 824)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.2

Use Curated BLAST to search for 1.3.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWS0 at UniProt or InterPro

Protein Sequence (379 amino acids)

>Echvi_1212 Acyl-CoA dehydrogenases (Echinicola vietnamensis KMM 6221, DSM 17526)
MNFTLTEEHLAVQEAAREFAKSALLPGVIERDTHATFPHEQVKQMGELGFLGMMVAPQYN
GGGMDTLSYVLAIEEISKIDASAAVAMSVNNSLVCWGLEHYGSEQQKEKYLKPLAAGEIL
GAFCLSEPEAGSDATSQRTMAEKHGDHYLLNGTKNWITNGGTASVYLVMAQTNPELKHKG
ISTFIVEKDMEGFQVGKKEDKLGIRGSDTHSLMFNDVKVPLENRIGEDGFGFTYAMHSLD
GGRIGIAAQALGIAAGAYELALAYSKERKAFGKPISQHQAIQFKLADMATEIEAARMLVW
KAAWLKDQGESYAHASAMAKLYASKVAMDTTIEAVQIHGGYGFVKEYHVERLMRDAKITQ
IYEGTSEIQKIVISRNLLR