Protein Info for Echvi_1178 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: phosphoglucosamine mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03990: phosphoglucosamine mutase
  • amino acids 4 to 452 (449 residues), 516.9 bits, E=2.4e-159
• PF02878: PGM_PMM_I
  • amino acids 8 to 140 (133 residues), 107.7 bits, E=7.8e-35
• PF02879: PGM_PMM_II
  • amino acids 161 to 262 (102 residues), 85 bits, E=9.5e-28
• PF02880: PGM_PMM_III
  • amino acids 269 to 374 (106 residues), 66.3 bits, E=5.5e-22
• PF00408: PGM_PMM_IV
  • amino acids 400 to 452 (53 residues), 32.7 bits, 1.3e-11

Best Hits

KEGG orthology group: K01840, phosphomannomutase [EC: 5.4.2.8] (inferred from 72% identity to mtt:Ftrac_2642)

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8) / Phosphoglucosamine mutase (EC 5.4.2.10)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis or Alginate metabolism or Mannose Metabolism (EC 5.4.2.10, EC 5.4.2.8)

MetaCyc Pathways

• D-galactose degradation I (Leloir pathway) (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• colanic acid building blocks biosynthesis (9/11 steps found)
• GDP-mannose biosynthesis (3/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• O-antigen building blocks biosynthesis (E. coli) (8/11 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• UDP-α-D-glucose biosynthesis (1/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (3/5 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• sucrose degradation II (sucrose synthase) (3/5 steps found)
• superpathway of anaerobic sucrose degradation (13/19 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (2/4 steps found)
• glycogen degradation II (3/6 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (3/6 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• starch degradation III (1/4 steps found)
• starch degradation V (1/4 steps found)
• peptidoglycan recycling I (8/14 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (8/14 steps found)
• chitin biosynthesis (4/9 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• glycogen degradation I (3/8 steps found)
• sucrose biosynthesis II (3/8 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (2/8 steps found)
• starch biosynthesis (3/10 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• streptomycin biosynthesis (2/18 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (4/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Fructose and mannose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.8

Use Curated BLAST to search for 5.4.2.10 or 5.4.2.8

Sequence Analysis Tools

See L0FU72 at UniProt or InterPro

Protein Sequence (463 amino acids)

>Echvi_1178 phosphoglucosamine mutase (Echinicola vietnamensis KMM 6221, DSM 17526)
MALIKSISGIRGTIGGKSGEGLTPVDIVKFTSAYGAWILEKTNNPRIVIGRDARISGDMV
SKLVTATLQGLGIQVIDLGLSTTPTVEFAVPLEKAGGGIILTASHNPIQWNALKLLNDKG
EFISDQDGKEVLEKAEKEDFEFATVKNIGAYTLVEDYIDRHIDHVLSLDLVDKEAIAARN
FRVVIDCVNSTGGIALPKLLKALGVEHVEEMYCEPDGHFPHNPEPLPENLRDISSKLKNG
KFDLGIVVDPDVDRLAFLTEDGSAFGEEYTLVAIADYVLSQTPGNTVSNLSSTRALRDVT
EKHEGTYNAAAVGEVNVVNKMKETNAIIGGEGNGGVIYPSSHYGRDALVGIGLFLTHLAK
FGKTANRLRASYPNYYISKNKIELTPEIDVDAILDEISRKYSKQPINDIDGIKIEFEKEW
VHLRKSNTEPIIRIYSESETKATAEHLANKLILDIKEVISASK