Protein Info for Echvi_1176 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: MazG family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 39% identical to MAZG_HAEIN: Nucleoside triphosphate pyrophosphohydrolase (mazG) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
KEGG orthology group: K02428, nucleoside-triphosphate pyrophosphatase [EC: 3.6.1.19] (inferred from 73% identity to dfe:Dfer_4447)MetaCyc: 39% identical to phosphoribosyl-ATP diphosphatase (Desulfovibrio vulgaris)
Phosphoribosyl-ATP diphosphatase. [EC: 3.6.1.31]
Predicted SEED Role
"Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8)" (EC 3.6.1.8)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- L-histidine biosynthesis (10/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Drug metabolism - other enzymes
- Histidine metabolism
- Purine metabolism
- Pyrimidine metabolism
Isozymes
Compare fitness of predicted isozymes for: 3.6.1.31
Use Curated BLAST to search for 3.6.1.19 or 3.6.1.31 or 3.6.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FVW3 at UniProt or InterPro
Protein Sequence (266 amino acids)
>Echvi_1176 MazG family protein (Echinicola vietnamensis KMM 6221, DSM 17526) MSKISSRSQQLEAFDRLLTIMDELREQCPWDRKQTIESLRHLTIEETFELSDAILDADLE EVKKELGDILLHIVFYAKIGEEKGAFDIATVIESLCEKLIRRHPHIYGDTEANDDEAVKQ NWEKIKLQEKGNKSVLGGVPRSLPALIKAMRIQEKARGVGFDWEDKAQVWEKVEEEMQEF KEAFDVTAPEDIDRERATGEFGDVLFSLINYARFVDINPEEALEKTNRKFIYRFQYLEEA AKKAGKNLGDMTLNEMDIFWNEAKKH