Protein Info for Echvi_1168 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 53% identical to YQHD_ECOLI: Alcohol dehydrogenase YqhD (yqhD) from Escherichia coli (strain K12)
KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 73% identity to cpi:Cpin_1126)MetaCyc: 53% identical to NADPH-dependent aldehyde reductase YqhD (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]
Predicted SEED Role
"NADH-dependent butanol dehydrogenase A (EC 1.1.1.-)" in subsystem Butanol Biosynthesis (EC 1.1.1.-)
MetaCyc Pathways
- pyruvate fermentation to butanol II (engineered) (5/6 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
- glycerol degradation to butanol (12/16 steps found)
- pyruvate fermentation to butanol I (6/8 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (3/4 steps found)
- erythritol biosynthesis I (1/2 steps found)
- erythritol biosynthesis II (1/2 steps found)
- methylglyoxal degradation III (1/2 steps found)
- 1,3-propanediol biosynthesis (engineered) (6/9 steps found)
- superpathway of methylglyoxal degradation (5/8 steps found)
- D-arabinose degradation V (1/3 steps found)
- D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
- detoxification of reactive carbonyls in chloroplasts (2/10 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (7/17 steps found)
- traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
- superpathway of lipoxygenase (4/22 steps found)
- superpathway of pentose and pentitol degradation (11/42 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Caprolactam degradation
- Ethylbenzene degradation
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Insect hormone biosynthesis
- Limonene and pinene degradation
- Linoleic acid metabolism
- Naphthalene and anthracene degradation
- Nucleotide sugars metabolism
- Pentose and glucuronate interconversions
- Polyketide sugar unit biosynthesis
- Pyruvate metabolism
- Retinol metabolism
- Tetrachloroethene degradation
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-, 1.1.1.2
Use Curated BLAST to search for 1.1.-.- or 1.1.1.- or 1.1.1.2 or 1.1.1.21
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FU61 at UniProt or InterPro
Protein Sequence (386 amino acids)
>Echvi_1168 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family (Echinicola vietnamensis KMM 6221, DSM 17526) MLNFEFKNPTKIIFGQGQTAKIADEIPAGAKVLMTYGGGSIKKNGIYDAVKDALKDFEVI EFGGIPANPAYHQLLDALKIIKEEGITFMLAVGGGSVIDATKFLSSAALYDGEEPWDILA KKIRTEEGLPFGTVLTIPATGSESNSGAVISNHQTGEKFSMGGPGLFPQFSLLDPTVIRT LPQRQLANGIMDAFSHALEQYMTYPVKAGLQDRFAESIMQTLIEVGPQVMKDPSDYDAAG DFMWCCTMALNGLIQKGVPTDWAIHAMGHELTALYGIDHARTLAIVAGSHYRYNLDRKKA KLAQYAERVWGIVDGTAEEKALAGIKKTEAFIQSLGIETQLSAYTDTYKTAAKEIADRFT SRGWTGLGEHKDLSPADVEKIVEMAY