Protein Info for Echvi_1151 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: dTDP-4-dehydrorhamnose 3,5-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01221: dTDP-4-dehydrorhamnose 3,5-epimerase
  • amino acids 4 to 174 (171 residues), 216.2 bits, E=1.4e-68
• PF00908: dTDP_sugar_isom
  • amino acids 6 to 174 (169 residues), 231.8 bits, E=1.9e-73

Best Hits

Swiss-Prot: 50% identical to RMLC_SHIFL: dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC) from Shigella flexneri

KEGG orthology group: K01790, dTDP-4-dehydrorhamnose 3,5-epimerase [EC: 5.1.3.13] (inferred from 59% identity to lby:Lbys_3333)

MetaCyc: 46% identical to dTDP-4-dehydrorhamnose 3,5-epimerase (Escherichia coli K-12 substr. MG1655)
dTDP-4-dehydrorhamnose 3,5-epimerase. [EC: 5.1.3.13]

Predicted SEED Role

"dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13)" in subsystem Capsular heptose biosynthesis or Rhamnose containing glycans or dTDP-rhamnose synthesis or linker unit-arabinogalactan synthesis (EC 5.1.3.13)

MetaCyc Pathways

• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• O-antigen building blocks biosynthesis (E. coli) (8/11 steps found)
• dTDP-4-O-demethyl-β-L-noviose biosynthesis (3/5 steps found)
• dTDP-L-daunosamine biosynthesis (3/6 steps found)
• dTDP-sibirosamine biosynthesis (3/6 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (5/19 steps found)
• superpathway of novobiocin biosynthesis (4/19 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)

KEGG Metabolic Maps

• Polyketide sugar unit biosynthesis
• Streptomycin biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.13

Sequence Analysis Tools

See L0FVT7 at UniProt or InterPro

Protein Sequence (183 amino acids)

>Echvi_1151 dTDP-4-dehydrorhamnose 3,5-epimerase (Echinicola vietnamensis KMM 6221, DSM 17526)
MEIRSTPIQDVYELYPRVFNDARGYFLETYREDLLAERGINTQWVQDNQSFSIAGTVRGL
HFQHAPHAQAKLVRVVTGKVYDVCVDLRKDSPTFGQCHGVILDSAQHNMLYVPEGFAHGF
SVLEDAVFSYKCSNFYHKPSEGGIIWNDRQLDIDWKVGAPIISDKDLELPSLEEFKQQTG
GGL