Protein Info for Echvi_0975 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: putative efflux protein, MATE family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 52 to 79 (28 residues), see Phobius details amino acids 99 to 117 (19 residues), see Phobius details amino acids 137 to 154 (18 residues), see Phobius details amino acids 166 to 189 (24 residues), see Phobius details amino acids 195 to 220 (26 residues), see Phobius details amino acids 258 to 279 (22 residues), see Phobius details amino acids 286 to 308 (23 residues), see Phobius details amino acids 321 to 342 (22 residues), see Phobius details amino acids 362 to 380 (19 residues), see Phobius details amino acids 392 to 412 (21 residues), see Phobius details amino acids 422 to 442 (21 residues), see Phobius details PF01554: MatE" amino acids 24 to 184 (161 residues), 127.6 bits, see alignment E=3.9e-41 amino acids 249 to 410 (162 residues), 109.7 bits, see alignment E=1.2e-35 TIGR00797: MATE efflux family protein" amino acids 24 to 420 (397 residues), 297.7 bits, see alignment E=6.2e-93 PF14667: Polysacc_synt_C" amino acids 138 to 228 (91 residues), 35.3 bits, see alignment E=1.2e-12

Best Hits

KEGG orthology group: None (inferred from 71% identity to mtt:Ftrac_1512)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWV7 at UniProt or InterPro

Protein Sequence (456 amino acids)

>Echvi_0975 putative efflux protein, MATE family (Echinicola vietnamensis KMM 6221, DSM 17526)
MQAPKEKKYTEGKLISALVSLALPIILANVLQTAYQLIDTFWLGRLGANAVAAVSVSFPI
LFLILSLGAGLTLAGTVLVSQHKGANNQKMVNSASSQTVFVVFCISVLLAIVGYFAAGPL
MKLIGAGPEIYSDSVDYFKVSSLGFVFLFMFFVFQSLMRGIGNVMLPVYVVLVTVLLNLV
LDPLFIYGFGPVPGFGVAGAAVASVITQGLSAIAGIYVMWKGKHGIQIHFSEMKWDLPWA
KKLFQLGLPSSMEQSARALGMTMMVVLVTSFGSETVAAYGVGARMLSFVIVPALGLAIAT
TTLVGQNVGARKLKRAEKTGFLSIKVAFIGLTAIGILLFVFAEDLVRFFVPNEPKVIEDG
ALFIKIMGPSFGFLGVQQVINGTFNGAGFTKASMFISFLNLWVIRFPVGYYLAYHTDLAH
VGIYWAFPISNWVSAIVAFIYFKTGYWRKRIEVGKA