Protein Info for Echvi_0877 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF02335: Cytochrom_C552" amino acids 50 to 484 (435 residues), 572.4 bits, see alignment E=7.2e-176

Best Hits

Swiss-Prot: 55% identical to NRFA_PARD8: Cytochrome c-552 (nrfA) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K03385, formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [EC: 1.7.2.2] (inferred from 76% identity to mtt:Ftrac_2736)

Predicted SEED Role

"Cytochrome c552 precursor (EC 1.7.2.2)" in subsystem Nitrate and nitrite ammonification or Soluble cytochromes and functionally related electron carriers (EC 1.7.2.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.7.2.2

Use Curated BLAST to search for 1.7.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWX9 at UniProt or InterPro

Protein Sequence (497 amino acids)

>Echvi_0877 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MKNWILFLITAVVVFLLAMLAYSIMDRKNEAKYAYQPKVDIGNIEPRDSIWGLNYPRQYQ
SYMKTKDTSFHSMYNTSGHAAVLEEDPELVILWAGYGFSKEYNQPKGHAHAVEDIRKILR
TGAPMEAGEGPMPSTCWTCKSPDVPRLMKEIGVTEFYSKKWSDLGAEVINPIGCADCHNP
ETMNLTITRPALIEAFEAMGKNINESSYQQMRSLVCAQCHVEYYFAKDAPGKEGAQYLTF
PWKDGMDVESMEAYYDELEFSDWVHPISKTPMLKAQHPDYELYSLGVHAKRGVSCADCHM
PYKTEGGQKFTDHHIGSPLSNVENSCFVCHREKKEDLITDVFERQRMVKQGAQKLMRLVA
MAHIEAGKAWELGAAEDQMKPIQEGIRHAQWRWDYAVASHGAAFHAPLPTNSIITSGTSI
IEEARLQLARLLADLGHNKPVEMPDFKDTEALQAYVGMDMEKQRAQKEKFLEEVVPKWLE
EGKKREAGYTIEMISNE