Protein Info for Echvi_0867 in Echinicola vietnamensis KMM 6221, DSM 17526

Updated annotation (from data): uvrA paralog in Bacteroidetes
Rationale: Specifically important in stress Cisplatin; stress D-Cycloserine. Both the "standard" uvrA and this gene were important for cisplatin resistance. (SEED_correct)
Original annotation: excinuclease ABC, A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 938 TIGR00630: excinuclease ABC subunit A" amino acids 21 to 921 (901 residues), 1108.1 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 148 to 255 (108 residues), 74.9 bits, see alignment E=2.1e-24 PF17755: UvrA_DNA-bind" amino acids 305 to 368 (64 residues), 51.1 bits, see alignment 6.8e-17

Best Hits

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 73% identity to mtt:Ftrac_1878)

Predicted SEED Role

"Excinuclease ABC subunit A paralog in greater Bacteroides group" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWX0 at UniProt or InterPro

Protein Sequence (938 amino acids)

>Echvi_0867 uvrA paralog in Bacteroidetes (Echinicola vietnamensis KMM 6221, DSM 17526)
MNETTALNPSSIENLDPKSYIIIKNARVNNLKNLSVAIPRNKLVVVTGLSGSGKSSLAFD
TLFAEGQRMYVESLSSYARQFLGRMEKPDVEYIKGVSPAIAIQQKVSTKNPRSTVGTTTE
IYDYLKLLFSRIGRTISPVSGEEVKHHTVTDVVDFIHGFEEGEKVMISCPLQANASRTMQ
KELEVLLQKGFTRIIIEGEVYYVEDLLEEKTIPDGDIEILIDRAVVRKDDEDNHFRIADS
VQTAFFEGHGDCFVVIPGKETRKFSDRFELDGLSFELPSVNFFSFNNPYGACKTCEGFGS
VLGIDPDLVIPDKSLSIYEGAIAPWRGETTKKWAAPLIKNGIHFDFPIHRPYEELDEAHK
DLIWKGNSYFKGLDAFFEHLQSKTHKIQYRVMLSRFRGRTTCPDCKGTRLRKDAAYVKVN
GHSITDIVLMPIDRALAFFQNIQLTEAEEKTANRLLKEILNRLEYIDKVGLGYLTLNRLT
SSLSGGEYQRIKLATSLGSALVGSMYILDEPSIGLHPRDSDRLISVLKSLRDMGNTVIVV
EHEEKIMKAADEIVDIGPEAGVNGGKLVFQGKLDELLAHGETYTAKYLKGEEKIDIKQGN
RKWKDKILINGARENNLKNINVQIPLNTLTVITGVSGSGKSTLIKKVLYPALGKILGTVI
DETGKFDKLEGDYKSISQVEFVDQNPIGKSSRSNPVTYVKAYDAIRSLFADQPVAKQRGY
KPAFFSFNVDGGRCEACQGEGTQKIEMQFMADIFLTCESCKGKRFKNEILDITYKDKNIA
DVLEMTIDEAMEFFQGKNAIISRLQPLQEVGLGYIGLGQSSNTLSGGEAQRVKLASFLGK
GGNKAKDHVLFIFDEPTTGLHFHDIKKLLYSINALIEEGHSVIIIEHNTEVIKSADWVID
LGPEGGERGGNVTFEGTPEALREVKDNYTAKYLRESFS