Protein Info for Echvi_0780 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 TIGR00585: DNA mismatch repair protein MutL" amino acids 5 to 306 (302 residues), 307.2 bits, see alignment E=9.1e-96 PF02518: HATPase_c" amino acids 24 to 80 (57 residues), 31.4 bits, see alignment 4.4e-11 PF13589: HATPase_c_3" amino acids 26 to 123 (98 residues), 41.6 bits, see alignment E=2.6e-14 PF01119: DNA_mis_repair" amino acids 211 to 326 (116 residues), 129.8 bits, see alignment E=8.3e-42 PF08676: MutL_C" amino acids 442 to 581 (140 residues), 112.3 bits, see alignment E=3.3e-36

Best Hits

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FWP9 at UniProt or InterPro

Protein Sequence (623 amino acids)

>Echvi_0780 DNA mismatch repair protein MutL (Echinicola vietnamensis KMM 6221, DSM 17526)
MSDIIQLLPDAIANQIAAGEVVQRPSSALKELLENAVDAGATDIQVLVKEAGKMLIQVID
NGKGMSITDARMCFERHATSKIRSSEDLFAIRTFGFRGEAMASIAAVAQVELKTRAKGEE
LGTLICIEGSEVKKQEPVVCPEGTSIAVKNLFFNVPARRNFLKSNPVEMKHIVEEFQRVA
LANPAVSFSLIHNDMELFKLSPGKLSQRIVGIFGKNYQSQLVSCEEETPHVSIKGYVGKP
ENAKKSRGEQYFFVNNRYIKSNYLNHAVSNAFEGLMSPDQHPFYVLFLELDPSHIDINVH
PTKTEIKFDDERTIYSVVRAGVKQALGAHNVVPTLDFSLDVNFTETWKHDEIKKDEVSRE
NSYKTYNSPTIKKQDTAGWERLFEGEKGINVRETAMRESEEESSALLTFSSRANEDEEHI
PAPTPMAQAFQSEDRTAGTTFQVELNYIVAQLGTGLLLIDQQASHERILYERYIKQLKNT
GGASQQCLFPQSLSLSLADYTLAMDLHEELNSLGFVLEEFGKNTLLIKGVPADVQINNEK
ALFEGLLEQFKHFKSELSLDNKENLARSLAKKSSIKKGTKLKSQEMETLVGQLFACQNPN
YGLSGNKTFVKLDLSKIRSFFEK