Protein Info for Echvi_0591 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Molecular chaperone GrpE (heat shock protein)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 206 PF01025: GrpE" amino acids 43 to 204 (162 residues), 135.5 bits, see alignment E=7.2e-44

Best Hits

Swiss-Prot: 42% identical to GRPE_BACFN: Protein GrpE (grpE) from Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)

KEGG orthology group: K03687, molecular chaperone GrpE (inferred from 52% identity to mtt:Ftrac_1940)

Predicted SEED Role

"Heat shock protein GrpE" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FSG5 at UniProt or InterPro

Protein Sequence (206 amino acids)

>Echvi_0591 Molecular chaperone GrpE (heat shock protein) (Echinicola vietnamensis KMM 6221, DSM 17526)
MLEQDSYSKGDMNKEKLAAEEQVEAQNQEVKNEEGAANNEEKTTEQATEEEPAEELSVEE
QLKAESQELKEKYLRLYSEFENYRRRTSKERLELIKTASEDVLKDLIPVVDDFERAIKAE
EKDAGGDQTLEGSLLIYNKLLKVLEAKGLTAMEDLIGKPFDADNQEAITQIPAPSEDMKG
KVIDVVEKGYKLGDKVVRFAKVVIGS