Protein Info for Echvi_0470 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: beta-ketoacyl-acyl-carrier-protein synthase II
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to FABF_STAAW: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (fabF) from Staphylococcus aureus (strain MW2)
KEGG orthology group: K09458, 3-oxoacyl-[acyl-carrier-protein] synthase II [EC: 2.3.1.179] (inferred from 74% identity to psn:Pedsa_3506)MetaCyc: 49% identical to 3-oxoacyl-[acyl-carrier-protein] synthase (Aerococcus viridans)
Beta-ketoacyl-acyl-carrier-protein synthase II. [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]; 2.3.1.179,2.3.1.41 [EC: 2.3.1.179, 2.3.1.41]
Predicted SEED Role
"3-oxoacyl-[acyl-carrier-protein] synthase, KASII (EC 2.3.1.179)" (EC 2.3.1.179)
MetaCyc Pathways
- superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
- superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
- palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
- oleate biosynthesis IV (anaerobic) (13/14 steps found)
- superpathway of unsaturated fatty acids biosynthesis (E. coli) (17/20 steps found)
- superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
- biotin biosynthesis I (13/15 steps found)
- palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (8/9 steps found)
- superpathway of fatty acid biosynthesis initiation (5/5 steps found)
- gondoate biosynthesis (anaerobic) (4/4 steps found)
- 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
- (5Z)-dodecenoate biosynthesis I (5/6 steps found)
- cis-vaccenate biosynthesis (4/5 steps found)
- fatty acid elongation -- saturated (4/5 steps found)
- octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (9/12 steps found)
- palmitate biosynthesis III (21/29 steps found)
- fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
- (5Z)-dodecenoate biosynthesis II (4/6 steps found)
- stearate biosynthesis II (bacteria and plants) (4/6 steps found)
- anteiso-branched-chain fatty acid biosynthesis (24/34 steps found)
- even iso-branched-chain fatty acid biosynthesis (24/34 steps found)
- odd iso-branched-chain fatty acid biosynthesis (24/34 steps found)
- petroselinate biosynthesis (3/6 steps found)
- stearate biosynthesis IV (3/6 steps found)
- streptorubin B biosynthesis (20/34 steps found)
- tetradecanoate biosynthesis (mitochondria) (12/25 steps found)
- mycolate biosynthesis (23/205 steps found)
- superpathway of mycolate biosynthesis (24/239 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.179
Use Curated BLAST to search for 2.3.1.179 or 2.3.1.41
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FVR1 at UniProt or InterPro
Protein Sequence (414 amino acids)
>Echvi_0470 beta-ketoacyl-acyl-carrier-protein synthase II (Echinicola vietnamensis KMM 6221, DSM 17526) MRRVVITGMGALTPIGNNVEDFWGSLKEGKSGAAPITKFDATKFKTKFACELKDFDPLQH IPRAEARKYDLFTQYALVAVAEAITHGKVDFDQLDKNRIGVIWGSGNGGLATFHQQVAEY VQGDGTPRFNPYFIPKMIVDIAAGVISIKYGLRGVNFAPVSACATSNTAIIDAFNHIKWN KAEMIITGGSEAAITESSIGGFGAAKALSTNNEHPETASRPFDVTRDGFVMGEGAGALVL EELEHAKRRGAPIIAEVVGGGMAADAYHLTGTHPEGEGAYLGMLAAMEEAGIGPESLDYI NMHATSTPLGDVSELKAIERIFGRDSKLSISATKSMTGHLLGAAGAIEAIASIKAIQHGI VPPTINCTEVEPAYKGVFDLTLGKAQERPVRYAMSNTFGFGGHIATAIFKAYEG