Protein Info for Echvi_0285 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: guanylate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00625: Guanylate_kin
  • amino acids 4 to 185 (182 residues), 154.1 bits, E=1.7e-49
• TIGR03263: guanylate kinase
  • amino acids 5 to 185 (181 residues), 203.9 bits, E=8.2e-65

Best Hits

Swiss-Prot: 67% identical to KGUA_CYTH3: Guanylate kinase (gmk) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K00942, guanylate kinase [EC: 2.7.4.8] (inferred from 72% identity to mtt:Ftrac_1822)

MetaCyc: 39% identical to guanylate kinase (Saccharomyces cerevisiae)
Guanylate kinase. [EC: 2.7.4.8]; T(2)-induced deoxynucleotide kinase. [EC: 2.7.4.8, 2.7.4.12, 2.7.4.13]

Predicted SEED Role

"Guanylate kinase (EC 2.7.4.8)" in subsystem MLST or Purine conversions (EC 2.7.4.8)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (9/9 steps found)
• superpathway of purine nucleotide salvage (12/14 steps found)
• purine deoxyribonucleosides salvage (6/6 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (7/8 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (4/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (11/14 steps found)
• dZTP biosynthesis (4/5 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (4/7 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.12 or 2.7.4.13 or 2.7.4.8

Sequence Analysis Tools

See L0FV04 at UniProt or InterPro

Protein Sequence (190 amino acids)

>Echvi_0285 guanylate kinase (Echinicola vietnamensis KMM 6221, DSM 17526)
MSSGKAFIFSAPSGSGKTTIVKHLLSSRNDLGFSISACTRDKRGRHEVHGKDYYFLSPQE
FKQKIDDDEFIEWEEVYEGNFYGTLKSEIQRIWDSGKHVIFDVDVKGGLQLKEYFGDKAL
AVFVKVPSLDTLEERLKDRGTESEESLSRRIYKAKFEMSFEDQFDVTLVNDHMEKSFKEA
EKLINAFIEK