Protein Info for Echvi_0202 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: histidine ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 48% identical to HUTH_NATTJ: Histidine ammonia-lyase (hutH) from Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)

KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 67% identity to hhy:Halhy_2980)

MetaCyc: 47% identical to HutH (Bacillus subtilis)
Histidine ammonia-lyase. [EC: 4.3.1.3]

Predicted SEED Role

"Histidine ammonia-lyase (EC 4.3.1.3)" in subsystem Histidine Degradation (EC 4.3.1.3)

MetaCyc Pathways

L-histidine degradation VI (5/8 steps found)
L-histidine degradation I (2/4 steps found)
L-histidine degradation III (2/6 steps found)
L-histidine degradation II (1/5 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FU21 at UniProt or InterPro

Protein Sequence (508 amino acids)

>Echvi_0202 histidine ammonia-lyase (Echinicola vietnamensis KMM 6221, DSM 17526)
MIEVLEKQEAYRVGEMPVTLERIYRVVSEGKRLELSSAAIERIQQCRAYLDDKIYKDEAA
LYYGINTGFGYLQQVRIDRNEIQQLQYNLLQSHACGVGEKVPKELVRLMLLTKIESLSRG
HSGVQLETVQRLVDFYNHDVLPVVYNQGSLGASGDLSPLSHLSLPLIGMGEVYFEGKVCP
SAQVLEQFGWQPVTLRSKEGLSLINGTQFMLSYGVHITQRAEALFRWADLIAAISVDGFN
GNLQPFNALIHRIRAHEGQVDTAASLRHYLEGSEIAQSKEKQVQDPYSFRCIPQVHGASK
DTLAFVKGTFEREADSVTDNPNIFPDEDEILSGGNFHGQPLALAFDYLAIAMAEIGSISE
RRTYQLLSGQRGLPLFLVDDPGLHSGLMIPQYTAASVVSENKQLCTPASVDSIVSSNGQE
DHVSMGANGATKCLRVLDNLEKILAIELLTAAQALEFRRPARSSEIVERLIGVYRDHVSF
NAQDRVLSVDIKNTIKFLRDRSVEEFEK