Protein Info for Echvi_0196 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 385 PF00072: Response_reg" amino acids 4 to 113 (110 residues), 111 bits, see alignment E=8.5e-36 PF00158: Sigma54_activat" amino acids 139 to 305 (167 residues), 242.2 bits, see alignment E=6.1e-76 PF14532: Sigma54_activ_2" amino acids 140 to 310 (171 residues), 92.7 bits, see alignment E=6.2e-30 PF07728: AAA_5" amino acids 163 to 299 (137 residues), 28.2 bits, see alignment E=4.2e-10 PF00004: AAA" amino acids 163 to 293 (131 residues), 29.6 bits, see alignment E=2.2e-10

Best Hits

Swiss-Prot: 44% identical to NTRX_AZOC5: Nitrogen assimilation regulatory protein NtrX (ntrX) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: None (inferred from 70% identity to chu:CHU_1965)

Predicted SEED Role

"Sigma-54 dependent transcriptional regulator/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FT85 at UniProt or InterPro

Protein Sequence (385 amino acids)

>Echvi_0196 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains (Echinicola vietnamensis KMM 6221, DSM 17526)
MPKILIIDDEKVIRSTLKEILEYEDYEIHEAQDGVEGLKKIESQDFDLVLCDIKMPKMDG
LEVLDKVYQSDKQPQFIMISAHGSIESAVEATKKGAFDFIPKPPDLNRLLLTVRNALEKK
DLVTETKVLKKKLSKKLDMVGESAAILQVKETIEKVAPTDARVLITGPNGTGKELVAHWL
HQKSGRNKSPFIAVNCAAIPAELIESELFGHEKGAFTSANKQRQGKFEQANGGTIFLDEI
GDMSLSAQAKVLRALQEHKISRVGGDKDIKIDVRVLAATNKDLKKEIEENNFREDLYHRL
SVILIQVPALKDRKEDIPLLVDRFLEDIAKEYGTTKKDIDDKAIAKLQEYPWTGNIRELR
NVVERLIILGGKTISLEDIKKYADF