Protein Info for Echvi_0113 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 transmembrane" amino acids 166 to 187 (22 residues), see Phobius details PF01039: Carboxyl_trans" amino acids 36 to 530 (495 residues), 490.2 bits, see alignment E=6.6e-151 PF03255: ACCA" amino acids 316 to 429 (114 residues), 25.9 bits, see alignment E=5.4e-10

Best Hits

KEGG orthology group: None (inferred from 71% identity to dfe:Dfer_3637)

Predicted SEED Role

"Methylcrotonyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism or Serine-glyoxylate cycle (EC 6.4.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.4

Use Curated BLAST to search for 6.4.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FUQ4 at UniProt or InterPro

Protein Sequence (541 amino acids)

>Echvi_0113 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) (Echinicola vietnamensis KMM 6221, DSM 17526)
MTTLENPKEKHLELIQQLIEKTTRTKRGGGKQRIEKEHAKGKLTARERIDYLMDDPHDFL
EIGTFAADGMYQEEGGCPSAGVIMGLGKVSGRMCVVVANDATVKAGAWFPMTAKKNLRAQ
EIAMENRLPIIYLVDSAGVFLPMQNEIFPDKEHFGRQFRNNAKMSAMGIVQVAAIMGSCV
AGGAYLPIMSDEALIVDQTGSIFLAGSYLVKAAIGESVDNETLGGATTHCEISGVTDNKY
DNDEECLAAIKRIFETLGAPETAGFDRKPAKAPAVAPEKVFERFPVDRAKPYDMHGILET
LVDADSFDEYKPDFGQTLLCGTARIDGWAVGILANQRKMVKTKKGELQMGGVIYSDSADK
AARFIMNCNQRKVPLLFIQDVSGFMVGSRAEHGGIIKDGAKMVNAMANSVVPKFTVMIGN
AYGAGNYAMCGKAYDPRLIVSWPTAQMAVMSGTSAAKTLLQIKVASLKKEGKVITSEDEE
QLLKEITDKYEEELSPYYAAARLWVDEVISPLDTREIVSKGIAAADHAPIKDRFNVGVIQ
T