Protein Info for EX28DRAFT_4530 in Enterobacter asburiae PDN3

Annotation: FOG: GGDEF domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 signal peptide" amino acids 1 to 15 (15 residues), see Phobius details amino acids 34 to 34 (1 residues), see Phobius details transmembrane" amino acids 16 to 33 (18 residues), see Phobius details amino acids 289 to 308 (20 residues), see Phobius details PF02743: dCache_1" amino acids 78 to 272 (195 residues), 49 bits, see alignment E=5.6e-17 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 354 to 508 (155 residues), 108.1 bits, see alignment E=1.9e-35 PF00990: GGDEF" amino acids 356 to 506 (151 residues), 108.6 bits, see alignment E=2.9e-35

Best Hits

KEGG orthology group: None (inferred from 90% identity to enc:ECL_00249)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>EX28DRAFT_4530 FOG: GGDEF domain (Enterobacter asburiae PDN3)
MALHSKKLSFTRPIMLSFAGIICSFVVIAVAVTLSQRKDFLEDYHKINSNFTHNLAVNYT
ESILRENDYILGRAAMYFSRNDRLNETLNVNPTQGLQMVMHLQNLMPTVSSISLADTQGH
YLRAPEVLPTEKSKTFDPRTRPWFVAQAEASIFSHYTRPYMDYFTGHPTVTLYKPLISPE
GRLKGTIAFHLDLTSMGYTLRQMVAPVQGEFFVVERDGAVVLHPDTGALFKQYVSEALMD
KMTSGEGHLYDKKSNAWYYYYSFTNPDWFVIYRVSGETLTDITRHETTIVGWGFALAAII
IILFGLYLRHASRSVLMHIINAIKTGDVSEAPRLEAMLSHTIQSNKEREMAYVRQATHDA
LTGCKNRRAFDSDIAELLNAQQPFAMALVDIDNFKSINDTLGHLTGDIVLRNVAREGIQI
MQPHHVSLYRYGGEEFAVIFQAEQMTSALSLLEAWRTAVEKRVWREENLRVTFSGGLGEW
HFEPLEQFVGSVDNALYSAKQQGKNRINRTSIS