Protein Info for EX28DRAFT_4052 in Enterobacter asburiae PDN3
Annotation: FOG: EAL domain
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to PDEH_ECOLI: Cyclic di-GMP phosphodiesterase PdeH (pdeH) from Escherichia coli (strain K12)
KEGG orthology group: None (inferred from 95% identity to enc:ECL_04928)MetaCyc: 71% identical to cyclic di-GMP phosphodiesterase PdeH (Escherichia coli K-12 substr. MG1655)
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]
Predicted SEED Role
"GGDEF/EAL domain protein YhjH"
Isozymes
Compare fitness of predicted isozymes for: 3.1.4.52
Use Curated BLAST to search for 3.1.4.52
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (257 amino acids)
>EX28DRAFT_4052 FOG: EAL domain (Enterobacter asburiae PDN3) MKSEQVIQRLSTTPEASIENLQEHRYWLQCERAYTYQPIYRTDGRLMAIEILTVVTHPSN PTQRIAPDRYFAEVAVRQRLDVLEEQLRMLATKQPFFEQHDILASVNVDGPTLLALRQNA KLQELIATLPWMRFELVEHVRLPQDSSFASICEYGPLWLDDFGTGMANFSALSEVRYDYI KVARDLFIMLRQTPEGRNLFTLLLQLMNRYCQGVIVEGVETLEEWRDVQNSPAAAAQGYY LSRPVPMDRLDSVITTL